Sodium Aurothiomalate Induces Ferroptosis by Targeting GPX4 via Gold-Dependent Thiomalate Covalent Modification
Martín Hugo, Lissy Z. F. Gross, Andresa Messias, Lucía Alcober-Boquet, Thibaut Vignane, Biplab Ghosh, Nesrine Aroua, Lora Denson, Susana Delgado‐Martín, Kamini Kaushal, Umut Yildiz, Sebastian Müller, Antonio Martı́nez-Ruiz, Dario Ariel Estrin, Hellmut G. Augustin, , Hamed Alborzinia
This study shows sodium aurothiomalate induces ferroptosis by covalently modifying GPX4 through a gold-dependent mechanism, leading to tumor growth reduction in preclinical models.
bioRxiv · Nov 13, 2025 · PreprintBiochemistry