An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
Loren Ornelas, Emilda Gomez, Lindsay Panther, Aaron P. Frank, Susan Lei, Berhan Mandefro, Maria G. Bañuelos, Brandon Shelley, Julia Kaye, Leandro de Araújo Lima, Stacia K. Wyman, Ryan G. Lim, Jie Wu, Jennifer T. Stocksdale, Malcolm Casale, , Leslie Michels Thompson
The paper performs an integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients to identify dysregulated pathways and validate them in vivo and in postmortem data.
bioRxiv · Nov 1, 2020 · PreprintNeuroscience