Lactate-fueled hydride transfer metabolon drives breast cancer metastasis
Sebastian Igelmann, Predrag Jovanovic, Véronique Bourdeau, Nicolas Curdy, Lesley Zhan, Ranveer Palia, David J. Papadopoli, Daina Zofija Avizonis, Marilène Paquet, Shannon McLaughlan, Tara Nincic-Gajic, Lorne Taylor, Jean‐François Trempe, Josie Ursini‐Siegel, Gerardo Ferbeyre, Ivan Topisirović
This study identifies a lactate-fueled metabolon involving LDHB and HTC that promotes breast cancer metastasis by reprogramming NAD metabolism.
bioRxiv · Jun 21, 2026 · PreprintCancer Biology