Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Christopher Nardone, Jingjing Gao, Hyuk‐Soo Seo, Julian Mintseris, Lucy Ort, Matthew C. J. Yip, Milen Negasi, Anna Besschetnova, Nolan Kamitaki, Steven P. Gygi, Sirano Dhe‐Paganon, Nikhil C. Munshi, Mariateresa Fulciniti, Michael E. Greenberg, Sichen Shao, , Xin Gu
This study reveals the structural basis of the midnolin-proteasome pathway and shows that midnolin downregulation promotes myeloma cell survival by enhancing IRF4 expression.
Molecular Cell · Jun 17, 2025Peer-reviewedCell Biology