Author

Luke Kalcheim

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Lauren MahoneyiD· 2 shared Nat MurreniD· 2 shared Rebecca M. RichardsiD· 2 shared Dominique R. SmithiD· 1 shared Hemakshi J. Mishra· 1 shared Isaac King· 1 shared Jarron RoyiD· 1 shared Joshua M. BrockmaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Lauren MahoneyORCID

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Author profile →

2 papers

Recent·Most cited

Disruption of the interferon-gamma axis limits chimeric antigen receptor T cell efficacy against acute myeloid leukemia

Nat Murren, Isaac King, Lauren Mahoney, Jarron Roy, Otto A. Kletzien, Madeline Collins, Sarah Geffe, Luke Kalcheim, Rebecca M. Richards

This study shows that blocking the interferon-gamma axis reduces CAR T cell effectiveness against AML by impairing antigen expression and cytotoxicity, suggesting caution with IFN-gamma inhibitors in AML treatment.

bioRxiv · Aug 31, 2026 · PreprintCancer Biology

Chimeric Antigen Receptors Transmit Co-stimulatory Domain Dependent Piconewton Forces to their Target

Hemakshi J. Mishra, Lauren Mahoney, Dominique R. Smith, Luke Kalcheim, Kartikey Kansal, Nat Murren, Myrna Chang, Rebecca M. Richards, Joshua M. Brockman

This study measures piconewton forces transmitted by CARs during antigen engagement, showing co-stimulatory domains are essential for force generation and early signaling.

bioRxiv · Oct 22, 2025 · PreprintImmunology