Joshua M. Brockman

This study shows how mechanical forces and substrate properties enhance T-cell receptor proofreading by delaying decision-making and improving ligand discrimination.

This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.

This paper introduces TensionDL, a deep learning model that predicts pN receptor tension maps from cell morphology and vinculin images, validated across cell types and substrate stiffnesses.

This study measures piconewton forces transmitted by CARs during antigen engagement, showing co-stimulatory domains are essential for force generation and early signaling.