K. Sanyal

The dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spindle assembly checkpoint response in Cryptococcus neoformans

This study shows that Sgo1 maintains SAC signals in Cryptococcus neoformans by regulating Aurora B kinase and PP1 levels at kinetochores, independent of Bub1 kinase activity.

Expansion microscopy reveals unique ultrastructural features of pathogenic budding yeast species

This study uses expansion microscopy to reveal unique sub-cellular structures in Candida albicans, showing a distinct SPB arrangement compared to Saccharomyces cerevisiae.

Microevolution of clade II isolates of Candida auris highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B

This study evolves two clade II Candida auris isolates to develop amphotericin B resistance, revealing distinct mechanisms and intra-clade heterogeneity in resistance acquisition.

A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans

The paper identifies CSA6 as a clade-specific cell cycle progression factor in Candida albicans, essential for mitotic exit and a potential antifungal target.

Mechanics of MTOC clustering and spindle positioning in budding yeast Cryptococcus neoformans

The paper investigates MTOC clustering and spindle positioning in Cryptococcus neoformans using a search and capture model and computational simulations.

Shugoshin promotes efficient activation of spindle assembly checkpoint and timely spindle disassembly

This study identifies a novel role of Sgo1 in facilitating spindle disassembly and maintaining the spindle assembly checkpoint in Candida albicans.

Vacuolar transporter Mnr2 safeguards mitochondrial integrity in aged cells

The paper shows that the vacuolar transporter Mnr2 maintains mitochondrial integrity in aged cells by regulating Mg+2 homeostasis, and exogenous Mg+2 restores mitochondrial structure and extends lifespan in mnr2 null cells.

Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages

This paper identifies centromeres in Phytophthora sojae using long-read sequencing and ChIP-seq, revealing transposon-rich, heterochromatic regions distinct from other SAR supergroup organisms.

Identification of bridgin, an unconventional linker, connects the outer kinetochore to centromeric chromatin

The paper identifies bridgin, a new linker protein in fungi, that connects the outer kinetochore to centromeric chromatin, differing from known linker proteins.

Aurora kinase Ipl1 facilitates bilobed distribution of clustered kinetochores to ensure error-free chromosome segregation in Candida albicans

This study shows that Ipl1 in C. albicans ensures proper kinetochore geometry for error-free chromosome segregation and ploidy maintenance.