Author

M. A. Erb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

B. F. Cravatt· 3 shared A. R. Ramos· 2 shared J. N. Asiaban· 2 shared T. R. Bishop· 2 shared Y. Zhang· 2 shared A. K. Chatterjee· 1 shared B. Karakyriakou· 1 shared B. Melillo· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

B. F. Cravatt

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Redirecting the pioneering function of FOXA1 with covalent small molecules

S. J. Won, Y. Zhang, C. J. Reinhardt, N. S. MacRae, K. E. DeMeester, E. Njomen, L. M. Hargis, J. R. Remsberg, B. Melillo, B. F. Cravatt, M. A. Erb

This study identifies covalent small molecules that bind FOXA1, altering its chromatin remodeling activity in prostate cancer cells.

bioRxiv · Mar 21, 2024Biochemistry

Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities

Y. Zhang, D. Remillard, U. Onubogu, B. Karakyriakou, J. N. Asiaban, A. R. Ramos, K. Bowland, T. R. Bishop, C. J. Ott, M. Janiszewska, B. F. Cravatt, M. A. Erb

The paper identifies collateral synthetic lethality between HDAC1 and HDAC2 in cancer cells and shows that targeting HDAC2 can suppress tumor growth by disrupting the NuRD complex.

bioRxiv · May 30, 2022Cancer Biology

Chemical inhibition of ENL/AF9 YEATS domains in acute leukemia

L. Garnar-Wortzel, T. R. Bishop, S. Kitamura, N. Milosevich, J. N. Asiaban, X. Zhang, Q. Zheng, E. Chen, A. R. Ramos, C. J. Ackerman, E. N. Hampton, A. K. Chatterjee, T. S. Young, M. V. Hull, K. B. Sharpless, , M. A. Erb

This study identifies a potent inhibitor of the ENL/AF9 YEATS domain and demonstrates its selective suppression of ENL-dependent leukemia genes.

bioRxiv · Dec 1, 2020Cancer Biology