S. Baumann

Targeting tumour-intrinsic neural vulnerabilities of glioblastoma

This study identifies neural vulnerabilities in glioblastoma by analyzing patient samples and model systems, revealing drug targets and pathways that can be exploited for treatment.

Heterodimers of functionally divergent ARF-GEF paralogues prevented by self-interacting dimerisation domain

The paper shows that GNOM and GNL1 ARF-GEFs form homodimers but not heterodimers due to self-interacting dimerisation domains, preventing potentially harmful interactions.

A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs

This study reconstitutes a mammalian mRNA transport system showing APC, kinesin-2, and KAP3 drive selective axonal mRNA transport via 3UTR guanine-rich sequences.

The multi PAM2 protein Upa2 functions as novel core component of endosomal mRNA transport

The paper identifies Upa2 as a novel core component of endosomal mRNA transport in fungal hyphae, showing it is essential for mRNA transport and localizes to endosomes via a GWW motif.