B. Wollscheid

Targeting tumour-intrinsic neural vulnerabilities of glioblastoma

This study identifies neural vulnerabilities in glioblastoma by analyzing patient samples and model systems, revealing drug targets and pathways that can be exploited for treatment.

Poxviruses package viral redox proteins in lateral bodies and modulate the host oxidative response

This study identifies the proteome of poxvirus lateral bodies and shows they contain redox proteins that modulate host oxidative stress responses.

Apicobasal surfaceome architecture encodes for polarized epithelial functionality and depends on tumor suppressor PTEN

The paper uses chemoproteomic surfaceome scanning to map apicobasal surfaceomes and shows PTEN regulates their organization and collective cell migration.

CD20 as a gatekeeper of the resting stage of human B cells

This study shows CD20 maintains the resting state of human B cells by organizing surface receptors, and its disruption leads to B cell activation and plasma cell differentiation.

Cell-Derived Vesicles as TRPC1 Channel Delivery Systems for the Recovery of Cellular Respiratory and Proliferative Capacities

This study shows that cell-derived vesicles from C2C12 myoblasts can restore mitochondrial function and proliferative capacity in recipient cells through TRPC1-mediated calcium entry.

De novo Classification of Mouse B Cell Types using Surfaceome Proteotype Maps

The paper develops autoCSC, a miniaturized surfaceome mapping technology, to classify mouse B cell types and identify developmental subpopulations.

Proteotype profiling unmasks a viral signaling network essential for poxvirus assembly and transcriptional competence

The paper identifies a viral signaling network regulated by F10 kinase and H1 phosphatase through phosphoproteomic analysis, revealing their roles in poxvirus assembly and transcriptional competence.