M. A. Morrissey

A genome-wide screen links peroxisome regulation with Wnt signaling through RNF146 and tankyrase

The paper identifies RNF146 and tankyrase as regulators of peroxisome function and links them to Wnt signaling through their role in PARsylation and beta-catenin degradation.

Prior Fc Receptor activation primes macrophages for increased sensitivity to IgG via long term and short term mechanisms

This study shows that prior Fc receptor activation primes macrophages to be more sensitive to IgG, enhancing phagocytosis through short- and long-term mechanisms.

Engineering water exchange is a safe and effective method for magnetic resonance imaging in diverse cell types

This study shows that overexpressing Aquaporin-1 in diverse cell lines does not harm cell viability or function, making it a safe tool for magnetic resonance imaging.

Tight nanoscale clustering of Fc gamma-receptors using DNA origami promotes phagocytosis

The paper shows that tightly clustering Fc gamma-receptors using DNA origami enhances phagocytosis by increasing receptor phosphorylation and downstream signaling efficiency.

CD47 suppresses phagocytosis by repositioning SIRPA and preventing integrin activation

This study reveals that CD47 suppresses phagocytosis by repositioning SIRPA and preventing integrin activation, offering new strategies for cancer immunotherapy.

Chimeric antigen receptors that trigger phagocytosis

This paper introduces CAR-Ps, chimeric antigen receptors that direct macrophages to engulf specific targets like cancer cells, showing over 40% reduction in cancer cell numbers in co-culture.