Trade-Offs Between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamase by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting.
C. H. P. Cheung, M. Alorabi, F. Hamilton, Y. Takebayashi, O. Mounsey, K. J. Heesom, P. B. Williams, M. Williams, M. Albur, A. P. MacGowan, M. B. Avison
The paper shows how meropenem resistance via NDM-1 in Enterobacteriales involves trade-offs between resistance and fitness, leading to sporadic resistance emergence in clinical settings.
bioRxiv · Oct 24, 2020Microbiology