M. B. Avison

Similarities Between Antibiotic-Resistant Escherichia coli from Raw Meat, Commercial Raw Dog Food and Those Causing Extraintestinal Human Infections: A Contemporaneous Geographically Focussed Genomic Epidemiology Study

This study compares antibiotic-resistant E. coli from raw meat, commercial raw dog food, and human infections, finding close genetic links between them.

Improving Nitrofurantoin Resistance Prediction in Escherichia coli from Whole Genome Sequence by Integrating NfsA/B Enzyme Assays

The paper identifies specific amino acid substitutions in NfsA and NfsB that reduce enzyme activity and cause nitrofurantoin resistance in E. coli, but finds that WGS alone cannot reliably predict resistance due to functional silent mutations and downregulated gene expression.

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

The paper shows that gene cassettes in an integron, amplified by IS26, confer resistance to amikacin and piperacillin/tazobactam, often leaving meropenem as the last-resort antibiotic.

Genomic epidemiology of third-generation cephalosporin-resistant Escherichia coli from Argentinian pig and dairy farms reveals animal-specific patterns of co-resistance and resistance mechanisms

This study identifies animal-specific patterns of third-generation cephalosporin resistance in E. coli from Argentinian pig and dairy farms, revealing differences in resistance mechanisms and co-resistance patterns.

Similarities and differences in molecular epidemiology of third-generation cephalosporin-resistant Escherichia coli carried by dogs living in urban and nearby rural settings and associated behavioural risk factors

This study compares third-generation cephalosporin-resistant E. coli in dogs from urban and rural areas, identifying risk factors and zoonotic transmission links with humans and cattle.

Identification and characterisation of Klebsiella pneumoniae and Pseudomonas aeruginosa clinical isolates with atypical β-lactam susceptibility profiles using Orbitrap liquid chromatography-tandem mass spectrometry

The paper uses proteomics and whole genome sequencing to characterize clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa with atypical β-lactam susceptibility profiles, expanding predictive rules for antibiotic resistance.

Klebsiella pneumoniae mutants resistant to ceftazidime/avibactam plus aztreonam, imipenem/relebactam, meropenem/vaborbactam and cefepime/taniborbactam.

The paper demonstrates that specific mutations in Klebsiella pneumoniae confer resistance to multiple beta-lactam combinations but not cefepime/taniborbactam.

Factors Influencing the Detection of Antibacterial Resistant Escherichia coli in Faecal Samples from Individual Cattle

This study examines factors affecting the detection of antibiotic-resistant E. coli in cattle faecal samples, finding that sampling methods and storage duration are more influential than on-farm antibiotic use.

OmpF Downregulation Mediated by Sigma E or OmpR Activation Confers Cefalexin Resistance in Escherichia coli in the Absence of Acquired β-Lactamases.

This study identifies OmpF downregulation via Sigma E or OmpR activation as a mechanism for cefalexin resistance in E. coli without β-lactamase production.

Limited Phylogenetic Overlap Between Fluoroquinolone-Resistant Escherichia coli Isolated on Dairy Farms and those Causing Bacteriuria in Humans Living in the Same Geographical Region

The paper investigates the link between fluoroquinolone-resistant E. coli on dairy farms and human bacteriuria in the same region, finding limited phylogenetic overlap and identifying farm use patterns as risk factors.

Evidence that faecal carriage of resistant Escherichia coli by 16-week-old dogs in the United Kingdom is associated with raw feeding

This study links raw feeding in 16-week-old UK dogs to carriage of antibiotic-resistant E. coli, with some strains shared with human infections.

Reduced antibacterial drug resistance and blaCTX-M β-lactamase gene carriage in cattle-associated Escherichia coli at low temperatures, at sites dominated by older animals and on pastureland: implications for surveillance.

This study identifies factors influencing antibacterial resistance in E. coli on dairy farms, showing that lower temperatures, older animal environments, and pastureland reduce resistance and blaCTX-M gene carriage.

Trade-Offs Between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamase by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting.

The paper shows how meropenem resistance via NDM-1 in Enterobacteriales involves trade-offs between resistance and fitness, leading to sporadic resistance emergence in clinical settings.

Molecular epidemiology of Escherichia coli producing CTX-M and plasmid AmpC-type β-lactamases from dairy farms identifies a dominant plasmid encoding CTX-M-32 but no evidence for transmission to humans in the same geographical region

The paper analyzes 3GC-R E. coli from dairy farms and human urinary samples in the same region, finding a dominant plasmid but no evidence of human transmission.

Novel mechanisms of efflux-mediated levofloxacin resistance and reduced amikacin susceptibility in Stenotrophomonas maltophilia.

This study identifies novel efflux pump mechanisms and regulatory systems contributing to levofloxacin resistance and amikacin susceptibility reduction in Stenotrophomonas maltophilia.

Variability in carbapenemase activity of intrinsic OxaAb (OXA-51-like) beta-lactamase enzymes in Acinetobacter baumannii

This study measures carbapenem susceptibility variability in OxaAb variants of Acinetobacter baumannii using WGS and LC-MS/MS, finding that ISAba1 promoter-driven overexpression of specific substitutions confers resistance.

Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae.

The paper identifies KvrA mutations that reduce OmpK35/36 porin expression and increase resistance to meropenem/vaborbactam in KPC-producing K. pneumoniae.

Proteomic Investigation of the Signal Transduction Pathways Controlling Colistin Resistance in Klebsiella pneumoniae.

This study uses proteomics to investigate how mutations in MgrB, PhoPQ, and PmrAB affect Arn protein production and colistin resistance in Klebsiella pneumoniae.

Resistance to Ceftazidime/Avibactam Plus Meropenem/Vaborbactam When Both are Used Together Achieved in Four Steps From Metallo-β-Lactamase Negative Klebsiella pneumoniae.

The paper identifies four genetic steps enabling resistance to the combination of ceftazidime/avibactam and meropenem/vaborbactam in K. pneumoniae.

Characterisation of AmpC Hyper-Producing Escherichia coli from Humans and Dairy Farms Collected in Parallel in the Same Geographical Region

This study characterizes AmpC hyper-producing E. coli from dairy farms and humans, identifies risk factors, and finds no evidence of zoonotic transmission.

Characterisation of cefotaxime-resistant urinary Escherichia coli from primary care in South-West England 2017-2018.

This study characterizes cefotaxime-resistant urinary E. coli from primary care in South-West England, finding blaCTX-M carriage as the most common resistance mechanism.

CreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and Carbapenems.

The paper identifies activatory mutations in the CreC sensor kinase that enhance Escherichia coli growth in the presence of cephalosporins and carbapenems without altering minimum inhibitory concentrations.

Imaging of sub-cellular fluctuations provides a rapid way to observe bacterial viability and response to antibiotics

This paper introduces SCFI, a method using TIRM to rapidly assess bacterial viability and antibiotic response by imaging sub-cellular fluctuations.

Prediction of fluoroquinolone susceptibility directly from whole genome sequence data using liquid chromatography-tandem mass spectrometry to identify mutant genotypes.

The paper predicts fluoroquinolone susceptibility in K. pneumoniae using whole genome sequence data and protein abundance measurements from liquid chromatography-tandem mass spectrometry.

The Envelope Proteome Changes Driven By RamA Overproduction in Klebsiella pneumoniae That Enhance Acquired β-Lactam Resistance

This study shows RamA overproduction in K. pneumoniae enhances β-lactam resistance by increasing efflux pumps and reducing OmpK35 porin, without altering β-lactamase levels.