Y. Takebayashi

Large-scale single-cell profiling of stem cells uncovers redundant regulators of shoot development and yield trait variation

This study uses single-cell RNA-seq to identify stem cell regulators in maize and Arabidopsis, revealing genes linked to yield traits and shoot development.

The endophytic fungus Serendipita indica alters auxin distribution in Arabidopsis thaliana roots through alteration of auxin transport and conjugation to promote plant growth

This study identifies how the endophytic fungus Serendipita indica promotes Arabidopsis growth by altering auxin transport and conjugation through GH3 genes and PIN2 expression.

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

The paper shows that gene cassettes in an integron, amplified by IS26, confer resistance to amikacin and piperacillin/tazobactam, often leaving meropenem as the last-resort antibiotic.

The trans-zeatin-type side-chain modification of cytokinins controls rice growth

This study identifies CYP735A3 and CYP735A4 as enzymes required for tZ-type cytokinin biosynthesis in rice, showing their role in growth promotion of both roots and shoots.

Small Molecule G-quadruplex Ligands are Antibacterial Candidates for Gram-negative Bacteria

The paper identifies a G-quadruplex ligand, L9, as a potential antibacterial agent against multi-drug resistant E. coli, showing superior activity and distinct mechanism compared to existing ligands.

Identification and characterisation of Klebsiella pneumoniae and Pseudomonas aeruginosa clinical isolates with atypical β-lactam susceptibility profiles using Orbitrap liquid chromatography-tandem mass spectrometry

The paper uses proteomics and whole genome sequencing to characterize clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa with atypical β-lactam susceptibility profiles, expanding predictive rules for antibiotic resistance.

Root-specific reduction of cytokinin perception enhances shoot growth with an alteration of trans-zeatin distribution in Arabidopsis thaliana

This study shows that reducing cytokinin perception in roots increases shoot growth by altering trans-zeatin distribution in Arabidopsis.

Regulation of ammonium acquisition and use in Oryza longistaminata ramets under nitrogen source heterogeneity

Oryza longistaminata regulates ammonium acquisition and use in response to spatial nitrogen heterogeneity through inter-ramet communication.

Phosphate starvation response precedes abscisic acid response under progressive mild drought in plants

The paper shows that phosphate starvation response precedes abscisic acid response in plants under mild drought, using field and controlled experiments.

Green Fluorescent Carbon Dots as Targeting Probes for LED-Dependent Bacterial Killing

This paper demonstrates that green fluorescent carbon dots can label and kill Gram-positive and Gram-negative bacteria when combined with LED light exposure.

The molecular framework of heterophylly in Callitriche palustris L. differs from that in other amphibious plants

This study investigates the molecular and developmental mechanisms of heterophylly in Callitriche palustris, revealing hormonal and transcriptional differences from other amphibious plants.

Trade-Offs Between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamase by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting.

The paper shows how meropenem resistance via NDM-1 in Enterobacteriales involves trade-offs between resistance and fitness, leading to sporadic resistance emergence in clinical settings.

Variability in carbapenemase activity of intrinsic OxaAb (OXA-51-like) beta-lactamase enzymes in Acinetobacter baumannii

This study measures carbapenem susceptibility variability in OxaAb variants of Acinetobacter baumannii using WGS and LC-MS/MS, finding that ISAba1 promoter-driven overexpression of specific substitutions confers resistance.

CreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and Carbapenems.

The paper identifies activatory mutations in the CreC sensor kinase that enhance Escherichia coli growth in the presence of cephalosporins and carbapenems without altering minimum inhibitory concentrations.

Prediction of fluoroquinolone susceptibility directly from whole genome sequence data using liquid chromatography-tandem mass spectrometry to identify mutant genotypes.

The paper predicts fluoroquinolone susceptibility in K. pneumoniae using whole genome sequence data and protein abundance measurements from liquid chromatography-tandem mass spectrometry.

The Envelope Proteome Changes Driven By RamA Overproduction in Klebsiella pneumoniae That Enhance Acquired β-Lactam Resistance

This study shows RamA overproduction in K. pneumoniae enhances β-lactam resistance by increasing efflux pumps and reducing OmpK35 porin, without altering β-lactamase levels.