Author

A. P. MacGowan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:E. coli· 4 Assay:whole-genome sequencing· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:clinical cohort / trial· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. B. Avison· 5 shared M. Williams· 4 shared J. Findlay· 3 shared K. J. Heesom· 3 shared P. B. Williams· 3 shared Y. Takebayashi· 3 shared K. E. Bowker· 2 shared O. Mounsey· 2 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersMicrobiology

M. B. Avison

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Author profile →

6 papers

Recent·Most cited

Development of antibacterial drug plus bacteriophage combination assays

M. E. Attwood, P. Griffin, A. R. NOEL, T. Josephs, K. Adler, M. R. Cloke, A. P. MacGowan

This study evaluates how phages interact with antibacterials using standardized assays and finds that phages can increase or decrease antibiotic MICs depending on the strain and combination.

bioRxiv · Mar 7, 2024 · PreprintMicrobiology

Identification and characterisation of Klebsiella pneumoniae and Pseudomonas aeruginosa clinical isolates with atypical β-lactam susceptibility profiles using Orbitrap liquid chromatography-tandem mass spectrometry

Y. Takebayashi, P. Dulyayangkul, N. Satapoomin, W. A. K. W. N. ISMAH, O. M. Williams, A. P. MacGowan, K. J. Heesom, P. B. Williams, M. B. Avison

The paper uses proteomics and whole genome sequencing to characterize clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa with atypical β-lactam susceptibility profiles, expanding predictive rules for antibiotic resistance.

bioRxiv · Feb 27, 2022 · PreprintMicrobiology

Limited Phylogenetic Overlap Between Fluoroquinolone-Resistant Escherichia coli Isolated on Dairy Farms and those Causing Bacteriuria in Humans Living in the Same Geographical Region

O. Mounsey, H. Schubert, J. Findlay, K. Morley, E. F. Puddy, V. C. Gould, P. North, K. E. Bowker, M. Williams, P. B. Williams, D. C. Barrett, T. A. Cogan, K. M. Turner, A. P. MacGowan, K. K. Reyher, M. B. Avison

The paper investigates the link between fluoroquinolone-resistant E. coli on dairy farms and human bacteriuria in the same region, finding limited phylogenetic overlap and identifying farm use patterns as risk factors.

bioRxiv · Apr 24, 2021Microbiology

Trade-Offs Between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamase by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting.

C. H. P. Cheung, M. Alorabi, F. Hamilton, Y. Takebayashi, O. Mounsey, K. J. Heesom, P. B. Williams, M. Williams, M. Albur, A. P. MacGowan, M. B. Avison

The paper shows how meropenem resistance via NDM-1 in Enterobacteriales involves trade-offs between resistance and fitness, leading to sporadic resistance emergence in clinical settings.

bioRxiv · Oct 24, 2020Microbiology

Characterisation of cefotaxime-resistant urinary Escherichia coli from primary care in South-West England 2017-2018.

J. Findlay, V. C. Gould, P. North, K. E. Bowker, M. Williams, A. P. MacGowan, M. B. Avison

This study characterizes cefotaxime-resistant urinary E. coli from primary care in South-West England, finding blaCTX-M carriage as the most common resistance mechanism.

Journal of Antimicrobial Chemotherapy · Sep 20, 2019Peer-reviewedMicrobiology

Prediction of fluoroquinolone susceptibility directly from whole genome sequence data using liquid chromatography-tandem mass spectrometry to identify mutant genotypes.

W. A. K. Wan Nur Ismah, Y. Takebayashi, J. Findlay, K. J. Heesom, J.-C. Jimenez-Castellanos, J. Zhang, L. Graham, K. Bowker, M. Williams, A. P. MacGowan, M. B. Avison

The paper predicts fluoroquinolone susceptibility in K. pneumoniae using whole genome sequence data and protein abundance measurements from liquid chromatography-tandem mass spectrometry.

bioRxiv · May 16, 2017Microbiology