M. Asad

A selective S-acyltransferase inhibitor suppresses tumor growth

The paper identifies an inhibitor of S-acyltransferase ZDHHC20 that suppresses Kras mutant lung tumor growth and improves survival.

Small-molecule inhibitors targeting prokaryotic ClpQ protease in Plasmodium display anti-malarial efficacies against blood and liver stages

This paper identifies small-molecule inhibitors of Plasmodium ClpQ protease that show anti-malarial activity against both blood and liver stages of malaria.

Dual role of an essential HtrA2/Omi protease in the human malaria parasite: maintenance of mitochondrial homeostasis and induction of apoptosis like cell death under cellular stress

This study identifies PfHtrA2's dual role in maintaining mitochondrial homeostasis and inducing apoptosis-like cell death in Plasmodium falciparum under stress.

A Plasmodium falciparum lysophospholipase regulates fatty acid acquisition for membrane biogenesis to enable schizogonic asexual division

This study identifies PfLPL3 as a key lysophospholipase in Plasmodium falciparum that facilitates fatty acid acquisition for membrane biogenesis, essential for asexual reproduction, and identifies potential anti-malarial inhibitors.

A lysophospholipase plays role in generation of neutral-lipids required for hemozoin formation in malaria parasite

This study identifies PfLPL1 as a lysophospholipase essential for generating neutral lipids required for hemozoin formation in malaria parasites, disrupting parasite growth and development.