Author

C. Y. Botte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:metabolomics· 3 Assay:proteomics· 3 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

Y. Yamaryo-Botte· 5 shared N. J. KATRIS· 3 shared A. Mohmmed· 2 shared C. J. TONKIN· 2 shared L. Berry· 2 shared M. Asad· 2 shared V. Thakur· 2 shared A. Cerutti· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersMicrobiology

Y. Yamaryo-Botte

Mutual co-authors in cluster

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8 papers

Recent·Most cited

Disrupting the plastid-hosted iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability

E. A. Renaud, S. Pamukcu, A. Cerutti, L. Berry, C. Lemaire-Vieille, Y. Yamaryo-Botte, C. Y. Botte, S. Besteiro

This study shows that disrupting the SUF iron-sulfur cluster pathway in Toxoplasma gondii severely impairs parasite growth and viability through multiple metabolic and functional defects.

bioRxiv · Mar 18, 2022Microbiology

A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in Toxoplasma gondii

C. Dominicus, S. D. Nofal, M. Broncel, N. J. Kastris, H. Flynn, G. Arrizabalaga, C. Y. Botte, B. M. Invergo, M. Treeck

The paper identifies a positive feedback loop linking calcium, cyclic nucleotide, and lipid signaling in Toxoplasma gondii during egress.

bioRxiv · Nov 29, 2021Microbiology

A Plasmodium falciparum lysophospholipase regulates fatty acid acquisition for membrane biogenesis to enable schizogonic asexual division

P. K. Sheokand, Y. Yamaryo-Botte, V. Thakur, M. M. Banday, M. Asad, C. Y. Botte, A. Mohmmed

This study identifies PfLPL3 as a key lysophospholipase in Plasmodium falciparum that facilitates fatty acid acquisition for membrane biogenesis, essential for asexual reproduction, and identifies potential anti-malarial inhibitors.

bioRxiv · Jul 1, 2021 · PreprintMicrobiology

The trypanosome UDP-glucose pyrophosphorylase is imported by piggybacking into glycosomes where unconventional sugar nucleotide synthesis takes place

O. Villafraz, H. Baudouin, M. Mazet, H. Kulyk, J.-W. Dupuy, E. Pineda, C. Y. Botte, D. Inaoka, J.-C. Portais, F. Bringaud

This study shows that UDP-glucose pyrophosphorylase (UGP) is imported into glycosomes by piggybacking on phosphoenolpyruvate carboxykinase (PEPCK) and that both cytosolic and glycosomal UGP pathways are functional in trypanosomes.

bioRxiv · Feb 17, 2021Microbiology

Rapid kinetics of lipid second messengers controlled by a cGMP signalling network coordinates apical complex functions in Toxoplasma tachyzoites

N. J. KATRIS, Y. YAMARYO-BOTTE, J. JANOUSKOVEC, S. SHUNMUGAM, C.-S. ARNOLD, A. S. P. YANG, A. VARDAKIS, R. STEWART, R. SAUERWEIN, G. McFADDEN, C. J. TONKIN, M.-F. CESBRON-DELAUW, C. Y. BOTTE

The paper investigates the rapid lipid second messenger dynamics in Toxoplasma tachyzoites, showing how cGMP signaling regulates membrane lipid turnover and coordinates invasion and egress.

bioRxiv · Jun 19, 2020 · PreprintMicrobiology

A lysophospholipase plays role in generation of neutral-lipids required for hemozoin formation in malaria parasite

M. Asad, Y. Yamaryo-Botte, M. E. Hossain, V. Thakur, S. Jain, G. Datta, C. Y. Botte, A. Mohmmed

This study identifies PfLPL1 as a lysophospholipase essential for generating neutral lipids required for hemozoin formation in malaria parasites, disrupting parasite growth and development.

bioRxiv · Oct 20, 2019 · PreprintMicrobiology

Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodelling

N. J. Katris, S. Amiar, L. Berry, S. Dass, M. J. Shears, C. Brunet, B. Touquet, M.-A. Hakimi, G. I. McFadden, Y. Yamaryo-Botte, C. Y. Botte

This study shows that apicomplexan parasites adapt to host nutritional changes by shifting lipid acquisition between de novo synthesis and host scavenging, involving apicoplast lipid metabolism and host organelle remodeling.

bioRxiv · Mar 22, 2019Microbiology

Protein Kinase A Negatively Regulates Ca2+ signalling in Toxoplasma gondii

A. D. Uboldi, M.-L. Wilde, E. A. McRae, R. J. Stewart, L. F. Dagley, L. Yang, N. J. Katris, S. V. Hapuarachchi, M. J. Coffey, A. M. Lehane, C. Y. Botte, R. F. Waller, A. I. Webb, C. J. Tonkin

This study shows that Protein Kinase A (PKAc1) suppresses Ca2+ signalling in Toxoplasma gondii after host cell invasion, affecting motility and infectivity.

bioRxiv · Feb 14, 2018Microbiology