Y. Yamaryo-Botte

This study shows that disrupting the SUF iron-sulfur cluster pathway in Toxoplasma gondii severely impairs parasite growth and viability through multiple metabolic and functional defects.

This study identifies PfLPL3 as a key lysophospholipase in Plasmodium falciparum that facilitates fatty acid acquisition for membrane biogenesis, essential for asexual reproduction, and identifies potential anti-malarial inhibitors.

The paper investigates the rapid lipid second messenger dynamics in Toxoplasma tachyzoites, showing how cGMP signaling regulates membrane lipid turnover and coordinates invasion and egress.

This study identifies PfLPL1 as a lysophospholipase essential for generating neutral lipids required for hemozoin formation in malaria parasites, disrupting parasite growth and development.

This study shows that apicomplexan parasites adapt to host nutritional changes by shifting lipid acquisition between de novo synthesis and host scavenging, involving apicoplast lipid metabolism and host organelle remodeling.