Author

J. S. Biteen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Microbiology· 4 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 6 Organism:bacteria (other)· 5 Approach:microscopy & imaging analysis· 5 Research Focus:cell type annotation· 4 Assay:fluorescence / live-cell microscopy· 4 Assay:imaging· 3 Research Focus:clustering· 2

Frequent Co-Authors

Z. Chen· 4 shared K. Ragunathan· 3 shared A. Farhat· 2 shared A. G. Vecchiarelli· 2 shared A. Gega· 2 shared A. L. Calkins· 2 shared C. A. Azaldegui· 2 shared E. D. Donarski· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersBiophysics

Z. Chen

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12 papers

Recent·Most cited

An experimental framework to assess biomolecular condensates in bacteria

Y. Hoang, C. A. Azaldegui, M. Ghalmi, J. S. Biteen, A. G. Vecchiarelli

This paper presents an experimental framework to study biomolecular condensates in E. coli, showing their formation, reversibility, and dynamics, and introduces a marker to distinguish condensates from aggregates.

bioRxiv · Mar 22, 2023Microbiology

Tracking live-cell single-molecule dynamics enables measurements of heterochromatin-associated protein-protein interactions

Z. Chen, M. Seman, A. Farhat, Y. Fyodorova, S. Biswas, A. Levashkevich, L. P. Freddolino, J. S. Biteen, K. Ragunathan

The paper uses live-cell single-molecule tracking to study how H3K9me affects HP1 protein interactions in fission yeast.

bioRxiv · Mar 8, 2023Biophysics

The BR-body proteome contains a complex network of protein-protein and protein-RNA interactions

V. Nandana, I. W. Rathnayaka-Mudiyanselage, N. S. Muthunayake, A. Hatami, C. B. Mousseau, L. A. Ortiz-Rodriguez, J. Vaishnav, M. Collins, A. Gega, K. S. Mallikaarachchi, H. Yassine, A. Ghosh, J. S. Biteen, Y. Zhu, M. M. Champion, , J. M. Schrader

The paper identifies 111 proteins enriched in bacterial RNP bodies (BR-bodies) and shows they form a complex network of protein-protein and protein-RNA interactions that regulate BR-body phase separation and RNA processing.

bioRxiv · Jan 18, 2023 · PreprintMicrobiology

Ruminococcus bromii enables the growth of proximal Bacteroides thetaiotaomicron by releasing glucose during starch degradation

A. Anandhi Rangarajan, H. Chia, C. Azaldegui, M. Olszewski, N. Koropatkin, J. S. Biteen

This study shows Ruminococcus bromii releases glucose during starch degradation, enabling Bacteroides thetaiotaomicron to grow and exhibit morphological changes.

bioRxiv · Feb 7, 2022Microbiology

Colicin E1 opens its hinge to plug TolC

S. J. Budiardjo, J. J. Stevens, A. L. Calkins, A. P. Ikujuni, V. K. Wimalasena, E. Firlar, D. Case, J. S. Biteen, J. Kaelber, J. S. G. Slusky

This paper reports the first structure of colicin E1 bound to TolC, showing how it opens its hinge to plug the channel and inhibit antibiotic efflux.

bioRxiv · Aug 24, 2021Biophysics

NOBIAS: Analyzing anomalous diffusion in single-molecule tracks with nonparametric Bayesian inference

Z. Chen, L. Geffroy, J. S. Biteen

NOBIAS analyzes single-molecule tracking data using nonparametric Bayesian inference and deep learning to identify diffusive states, transitions, and anomalous diffusion in live-cell experiments.

bioRxiv · Jul 15, 2021Biophysics

Independent Promoter Recognition by TcpP Precedes Cooperative Promoter Activation by TcpP and ToxR

A. L. Calkins, L. M. Demey, J. D. Karslake, E. D. Donarski, J. S. Biteen, V. J. DiRita

The paper investigates TcpP's ability to recognize the toxT promoter independently of ToxR using single-molecule tracking in live cells.

bioRxiv · Apr 25, 2021Microbiology

HP1 oligomerization compensates for low-affinity H3K9me recognition and provides a tunable mechanism for heterochromatin-specific localization

S. Biswas, J. Karslake, Z. Chen, A. Farhat, P. Freddolino, J. S. Biteen, K. Ragunathan

This study investigates how HP1 proteins recognize H3K9me with high specificity despite low-affinity binding, showing that oligomerization compensates for this and enables heterochromatin localization.

bioRxiv · Jan 26, 2021Biophysics

The emergence of phase separation as an organizing principle in bacteria

C. A. Azaldegui, A. G. Vecchiarelli, J. S. Biteen

This review evaluates methodologies for studying membraneless organelles in bacteria, discusses challenges in determining phase separation, and outlines future directions for research.

bioRxiv · Aug 5, 2020Biophysics

The condensation of HP1-????/Swi6 imparts nuclear stiffness

J. F. Williams, I. V. Surovtsev, S. M. Schreiner, Z. Chen, G. Raiymbek, H. Nguyen, Y. Hu, J. S. Biteen, S. Mochrie, K. Ragunathan, M. C. King

This study shows that Swi6 condensation provides mechanical stiffness to the nucleus, demonstrating a mechanical function of biomolecular condensates.

bioRxiv · Jul 2, 2020Cell Biology

BR-bodies provide selectively permeable condensates that stimulate mRNA decay and prevent release of decay intermediates

N. Al-Husini, D. T. Tomares, Z. Pfaffenberger, N. S. Muthunayake, M. A. Samad, T. Zuo, O. Bitar, J. R. Aretakis, M. H. M. Bharmal, A. Gega, J. S. Biteen, W. S. Childers, J. M. Schrader

The paper identifies RNA substrates of BR-bodies and shows they stimulate mRNA decay while preventing toxic intermediates.

bioRxiv · Jul 5, 2019Biochemistry

SMAUG: Analyzing single-molecule tracks with nonparametric Bayesian statistics

J. Karslake, E. D. Donarski, S. A. Shelby, L. M. Demey, V. J. DiRita, S. L. Veatch, J. S. Biteen

SMAUG uses nonparametric Bayesian statistics to analyze single-molecule trajectories, providing mobility states, diffusion coefficients, and transition probabilities in both prokaryotic and eukaryotic systems.

bioRxiv · Mar 15, 2019Biophysics