Author

M. C. Kiritsy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1

Frequent Co-Authors

C. M. Sassetti· 2 shared C. M. Smith· 2 shared A. E. Lord· 1 shared A. J. Olive· 1 shared A. Olive· 1 shared F. Pardo-Manuel de Villena· 1 shared G. P. Huizinga· 1 shared J. D. Trombley· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

C. M. Sassetti

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Author profile →

3 papers

Recent·Most cited

A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

M. C. Kiritsy, L. M. Ankley, J. D. Trombley, G. P. Huizinga, A. E. Lord, P. Orning, R. Elling, K. A. Fitzgerald, A. Olive

This study identifies new regulators of IFNγ-induced MHCII in macrophages using CRISPR screens, revealing pathways involving GSK3β and MED16 that are critical for CD4+ T cell activation.

bioRxiv · Aug 12, 2020Immunology

Functionally overlapping variants control TB susceptibility in Collaborative Cross mice

C. M. Smith, M. K. Proulx, R. Lai, M. C. Kiritsy, T. A. Bell, P. Hock, F. Pardo-Manuel de Villena, M. T. Ferris, R. E. Baker, S. M. Behar, C. M. Sassetti

The paper identifies multiple genetic loci associated with tuberculosis susceptibility in Collaborative Cross mice, including a loss-of-function mutation in Itgal that impairs T cell recruitment.

bioRxiv · Sep 28, 2019Microbiology

The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis infection.

A. J. Olive, C. M. Smith, M. C. Kiritsy, C. M. Sassetti

This study shows that the Phox complex promotes tolerance to Mycobacterium tuberculosis infection by preventing uncontrolled Caspase1 activation and neutrophil influx.

bioRxiv · Dec 21, 2017Immunology