R. E. Baker

Spatial heterogeneity in collective electrotaxis: continuum modelling and applications to optimal control

This study develops a continuum model to explain spatial velocity heterogeneity in collective electrotaxis and applies it to design electric field protocols for controlled tissue migration.

Reliable and efficient parameter estimation using approximate continuum limit descriptions of stochastic models

This paper develops a method to improve parameter estimation in stochastic models by combining continuum approximations with statistical discrepancy correction, showing better accuracy with minimal computational cost.

Mathematical modelling of autoimmune myocarditis and the effects of immune checkpoint inhibitors

This paper develops a mathematical model of autoimmune myocarditis and shows how immune checkpoint inhibitors increase its risk.

Parameter identifiability and model selection for sigmoid population growth models

The paper assesses parameter identifiability and model selection for sigmoid growth models using coral regrowth data, finding logistic models are identifiable while Gompertz and Richards models are not.

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

This study maps chemical-genetic interactions in Mycobacterium tuberculosis to identify how carbon metabolism and cell wall structure affect drug efficacy, revealing environment-dependent and -independent interactions.

Quantifying the impact of electric fields on single-cell motility

The paper develops and calibrates a stochastic model to predict how electric fields affect single-cell motility, showing that EFs bias motility through one of several hypothetical mechanisms.

The role of mechanical interactions in EMT

This study presents a mathematical model of mechanical cellular processes driven by EMT and explores their influence on cell behavior.

Mechanical cell competition in heterogeneous epithelial tissues

The paper develops a mechanical model to study how cancer cells outcompete normal cells in epithelial tissues through mechanical differences rather than proliferation rates.

Climate and urbanization drive mosquito preference for humans

This study identifies ecological and genetic factors driving human-biting behavior in Aedes aegypti mosquitoes, linking it to climate and urbanization.

Practical parameter identifiability for spatiotemporal models of cell invasion

This study assesses parameter identifiability in a spatiotemporal reaction-diffusion model of cell invasion using Bayesian MCMC and profile likelihood methods, finding that parameters are identifiable when subpopulation diffusivities are equal but not when they differ.

Functionally overlapping variants control TB susceptibility in Collaborative Cross mice

The paper identifies multiple genetic loci associated with tuberculosis susceptibility in Collaborative Cross mice, including a loss-of-function mutation in Itgal that impairs T cell recruitment.

Accurate and efficient discretisations for stochastic models providing near agent-based spatial resolution at low computational cost

This paper introduces a computationally efficient stochastic agent-based model that balances resolution and cost, matching continuum models in relevant parameter regimes.

A one-dimensional individual-based mechanical model of cell movement in heterogeneous tissues and its coarse-grained approximation

The paper develops a multi-scale mathematical model to connect cellular-level mechanical properties with tissue-level outcomes, showing convergence between individual-based and coarse-grained models.

Discrete and continuum approximations for collective cell migration in a scratch assay with cell size dynamics

This paper develops a stochastic model and continuum approximations to study collective cell migration in scratch assays with cell size dynamics, showing improved accuracy with moment dynamics over mean-field approximations.

The impact of experimental design choices on parameter inference for models of growing cell colonies

This study investigates how experimental design affects parameter inference in models of growing cell colonies, finding that initial spatial heterogeneity improves inference without cell tracking.

Continuum approximations for lattice-free multi-species models of collective cell migration

The paper develops a discrete model of multi-species cell migration and compares two continuum approximations for their accuracy under different adhesive force conditions.

A new and accurate continuum description of moving fronts

This paper introduces a new continuum description for moving fronts in population processes, accurately predicting population persistence or extinction across all parameter regimes.