S. M. Behar

Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is determined by T cells

This study shows that T cell responses differentially affect M. tuberculosis control in alveolar macrophages versus monocyte-derived macrophages, influencing infection outcomes.

High bacillary burden and the ESX-1 type VII secretion system promote MHC class I presentation by Mycobacterium tuberculosis infected macrophages to CD8 T-cells

The paper shows high Mtb burden in macrophages leads to cell death and cross-presentation of TB10.4 antigen to CD8 T-cells via the ESX-1 system, promoting immune response but potentially worsening immunopathology.

Identification and characterization of the T cell receptor (TCR) repertoire of the Cynomolgus macaque (Macaca Fascicularis)

The paper characterizes the T cell receptor repertoire in Cynomolgus macaques using single-cell RNA sequencing and identifies similarities with human and Rhesus macaque TCR repertoires.

IFNγ and iNOS-mediated alterations in the bone marrow and thymus and its impact on Mycobacterium avium-induced thymic atrophy

This study investigates how IFNγ and iNOS contribute to M. avium-induced thymic atrophy by affecting bone marrow progenitors and thymic stroma.

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

This study shows CD4 T cell help enhances CD8 T cell function and prevents exhaustion during M. tuberculosis infection, suggesting vaccines targeting both cell types may be more effective.

Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells

This study identifies mitochondrial respiration as essential for the interferon gamma response in antigen presenting cells, showing that complex I inhibition blocks T cell activation.

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

Functionally overlapping variants control TB susceptibility in Collaborative Cross mice

The paper identifies multiple genetic loci associated with tuberculosis susceptibility in Collaborative Cross mice, including a loss-of-function mutation in Itgal that impairs T cell recruitment.

Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice

The paper assesses T cell recognition of Mtb-infected macrophages in mice and finds that CD4 T cells more effectively recognize these cells than CD8 T cells, with BCG vaccination eliciting such responses.

Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages

This study compares CD4+ and CD8+ T cell recognition of Mtb-infected macrophages, finding CD8+ T cells poorly recognize infected macrophages despite strong immunodominant responses.