Author

M. K. Proulx

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

C. M. Sassetti· 3 shared C. Trujillo· 2 shared K. C. Murphy· 2 shared K. G. Papavinasasundaram· 2 shared K. M. Guinn· 2 shared M. Fitzgerald· 2 shared N. Ruecker· 2 shared R. E. Baker· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

C. M. Sassetti

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Author profile →

4 papers

Recent·Most cited

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

E.-I. Koh, P. O. Oluoch, N. Ruecker, M. K. Proulx, V. Soni, K. C. Murphy, K. G. Papavinasasundaram, C. J. Reames, C. Trujillo, A. Zaveri, M. D. Zimmerman, R. Aslebagh, R. E. Baker, S. A. Shaffer, K. M. Guinn, , C. M. Sassetti

This study maps chemical-genetic interactions in Mycobacterium tuberculosis to identify how carbon metabolism and cell wall structure affect drug efficacy, revealing environment-dependent and -independent interactions.

bioRxiv · Apr 8, 2021Microbiology

Functionally overlapping variants control TB susceptibility in Collaborative Cross mice

C. M. Smith, M. K. Proulx, R. Lai, M. C. Kiritsy, T. A. Bell, P. Hock, F. Pardo-Manuel de Villena, M. T. Ferris, R. E. Baker, S. M. Behar, C. M. Sassetti

The paper identifies multiple genetic loci associated with tuberculosis susceptibility in Collaborative Cross mice, including a loss-of-function mutation in Itgal that impairs T cell recruitment.

bioRxiv · Sep 28, 2019Microbiology

Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes

E. O. Johnson, E. LaVerriere, M. Stanley, E. Office, E. Meyer, T. Kawate, J. Gomez, R. E. Audette, N. Bandyopadhyay, N. Betancourt, K. Delano, I. Da Silva, J. Davis, C. Gallo, M. Gardner, , Schnappinge

This study uses a novel chemical-genetics screening strategy to identify new inhibitors of Mycobacterium tuberculosis, revealing novel compound classes targeting previously unexplored bacterial targets.

bioRxiv · Jan 16, 2019Microbiology

Gain of Function Analysis Reveals Non-Redundant Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA

S. G. Palace, M. K. Proulx, R. L. Szabady, J. D. Goguen

The paper identifies non-redundant roles of YopJ, YopT, and YpkA in Yersinia pestis virulence by showing that their combined absence attenuates virulence, while each individually restores lethality.

bioRxiv · Apr 28, 2018Microbiology