Author

S. R. Margolis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:bacteria (other)· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:non-human primate· 1

Frequent Co-Authors

R. E. Vance· 3 shared A. J. Meeske· 2 shared A. Y. Lee· 2 shared D. A. Portnoy· 2 shared M. C. Williams· 2 shared A. E. Reker· 1 shared A. Kozlova· 1 shared A. Louie· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersImmunology

R. E. Vance

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Diverse viral cas genes antagonize CRISPR immunity

M. A. Katz, E. M. Sawyer, A. Kozlova, M. C. Williams, S. R. Margolis, L. Oriolt, M. Johnson, J. Bondy-Denomy, A. J. Meeske

The paper identifies novel anti-CRISPR genes in Listeria isolates that antagonize diverse CRISPR-Cas systems, revealing evolutionary mechanisms of Acrs through cas gene co-option.

bioRxiv · Jun 24, 2023Microbiology

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens

H. M. Morrison, J. Craft, R. Rivera-Lugo, J. R. Johnson, G. R. Golovkine, C. E. Dodd, E. Van Dis, W. L. Beatty, S. R. Margolis, T. Repasy, I. Shaker, A. Y. Lee, R. E. Vance, S. A. Stanley, N. J. Krogan, , J. S. Cox

bioRxiv · Dec 29, 2022 · PreprintImmunology

Phage genome cleavage enables resuscitation from Cas13-induced bacterial dormancy

M. C. Williams, A. E. Reker, S. R. Margolis, J. Liao, M. Wiedmann, E. R. Rojas, A. J. Meeske

This study shows that type VI CRISPR systems and DNA-cleaving restriction modification systems work together to eliminate phage DNA and neutralize infection in Listeria seeligeri.

bioRxiv · Jul 5, 2022Microbiology

The cyclic dinucleotide 2'3'-cGAMP induces a broad anti-bacterial and anti-viral response in the sea anemone Nematostella vectensis

S. R. Margolis, P. A. Dietzen, B. M. Hayes, S. C. Wilson, B. C. Remick, S. Chou, R. E. Vance

This study shows that 23-cGAMP induces both anti-viral and anti-bacterial gene expression in the sea anemone Nematostella vectensis, suggesting an ancestral role for cyclic dinucleotide signaling in immunity.

bioRxiv · May 13, 2021Immunology

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

D. X. Ji, K. C. Witt, D. I. Kotov, S. R. Margolis, A. Louie, V. Chevee, K. J. Chen, M. Gaidt, H. S. Dhaliwal, A. Y. Lee, S. Nishimura, D. S. Zamboni, I. Kramnik, D. A. Portnoy, K. H. Darwin, R. E. Vance

This study identifies SP140 as a repressor of type I interferons that enhances resistance to bacterial infections like Legionella pneumophila and Mycobacterium tuberculosis.

bioRxiv · Jan 7, 2020Immunology