Author

A. J. Drake

Carilion Roanoke Memorial Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metagenomics· 1

Frequent Co-Authors

M. C. Sinton· 3 shared D. C. Hay· 2 shared N. M. Morton· 2 shared A. A. S. Tavares· 1 shared A. Lovdel· 1 shared A. Poloni· 1 shared A. Thakker· 1 shared B. J. Thomas· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

M. C. Sinton

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery of Novel Probiotic Species to Improve Infant Health

Ran Lu, Nakyung Lee, A. J. Drake, Ryan P. Fulton, Nader S. Abutaleb, Mohamed N. Seleem, David Noah Oakland, Monica P. Garin-Laflam, Mihai Pop, Xin Luo

The paper identifies novel probiotic bacteria associated with IgA responses against enteric pathogens in infants, suggesting their potential use in improving infant formula.

bioRxiv · Oct 27, 2025 · PreprintMicrobiology

Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation

M. C. Sinton, B. Lucendo Villarin, J. Meseguer Ripolles, S. Wernig-Zorc, J. P. Thomson, P. D. Walker, A. Thakker, G. G. Lavery, C. Ludwig, D. A. Tennant, D. C. Hay, A. J. Drake

This study identifies fumarate accumulation driven by purine nucleotide cycle activity as a cause of macrovesicular steatosis in NAFLD using human pluripotent stem cell-derived hepatocytes.

bioRxiv · Jun 23, 2020Biochemistry

Nonalcoholic fatty liver disease is associated with decreased hepatocyte mitochondrial respiration but not mitochondrial number

M. C. Sinton, J. Meseguer-Ripolles, B. Lucendo-Villarin, M. J. Lyall, R. N. Carter, N. M. Morton, D. C. Hay, A. J. Drake

This study shows that NAFLD is linked to reduced mitochondrial respiration but not mitochondrial number or fragmentation in a human stem cell model.

bioRxiv · Mar 10, 2020 · PreprintBiochemistry

Bone marrow adipose tissue is a unique adipose subtype with distinct roles in systemic glucose homeostasis

K. J. Suchacki, A. A. S. Tavares, D. Mattiucci, E. L. Scheller, G. Papanastasiou, C. Gray, M. C. Sinton, L. E. Ramage, W. A. McDougald, A. Lovdel, R. J. Sulston, B. J. Thomas, B. M. Nicholson, A. J. Drake, C. Alcaide-Corral, , W. P. Cawthorn

This study identifies bone marrow adipose tissue (BMAT) as a distinct adipose subtype with unique metabolic functions in glucose homeostasis.

bioRxiv · Jun 18, 2019Physiology