A Spike Trimer Dimer-Inducing Nanobody with Anti-Sarbecovirus Activity
I. C. Swart, O. J. Debski Antoniak, A. Zegar, T. de Bouter, M. Chatziandreou, M. van den Berg, I. Drulyte, K. Pyrc, C. A. M. de Haan, D. L. Hurdiss, B.-J. Bosch, S. Oliveira
This paper describes a nanobody, 7F, that neutralizes SARS-CoV-2 and cross-neutralizes SARS-CoV and SARS-like CoV pseudoviruses by inducing spike trimer dimers and shows therapeutic potential in 3D tissue cultures.
bioRxiv · Jun 19, 2024 · PreprintMicrobiology