M. D. Lee

Increased TRPV4 channel expression enhances and impairs blood vessel function in hypertension

This study shows that increased TRPV4 channel expression in endothelial cells both enhances and impairs vascular function in hypertension, leading to altered Ca2+ signaling and vascular reactivity.

Importance of Mobile Genetic Element Immunity in Numerically Abundant Trichodesmium Clades

This paper identifies CRISPR-Cas immunity in Trichodesmium thiebautii as a factor contributing to its numerical dominance over T. erythraeum in oceanic nitrogen fixation.

Mitochondrial ATP production is required for endothelial cell control of vascular tone

This study shows that mitochondrial ATP production is essential for endothelial cell regulation of vascular tone across species, affecting calcium activity and nitric oxide signaling.

Why Environmental Biomarkers Work: Transcriptome-Proteome Correlations and Modeling of Multi-Stressor Experiments in the Marine Bacterium Trichodesmium

The paper examines transcriptome-proteome correlations in Trichodesmium under multi-stressor conditions, showing coherence in stress response biomarkers and discordance in metabolic pathways.

Vaginal Isolates of Candida glabrata are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae.

The paper shows that C. glabrata is inhibited by S. cerevisiae killer toxins despite resistance to antifungals.

The hunt for ancient prions: Archaeal prion-like domains form amyloids and substitute for yeast prion domains

This paper identifies prion-like domains in Archaea that form amyloids and transmit non-Mendelian inheritance, suggesting prions existed in the last universal common ancestor.

Dual thermal ecotypes co-exist within a nearly genetically-identical population of the unicellular marine cyanobacterium Synechococcus

The study identifies two thermal ecotypes within a nearly genetically identical Synechococcus population, showing functional diversity in temperature adaptation.

Disrupted Endothelial Cell Heterogeneity and Network Organization Impairs Vascular Function in Prediabetic Obesity

This study shows that disrupted endothelial cell heterogeneity and network organization in prediabetic obesity impair vascular function by altering calcium signaling and communication patterns.

The design and implementation of restraint devices for the injection of pathogenic microorganisms into Galleria mellonella.

This paper describes the design of injection chambers to safely restrain Galleria mellonella larvae during pathogen injection, reducing needlestick risks and improving experimental consistency.

Genomic and phenotypic characterization of Burkholderia isolates from the potable water system of the International Space Station

This paper characterizes Burkholderia isolates from the ISS potable water system, finding they are genetically similar but show phenotypic differences and increased antibiotic sensitivity.

Negative plant-microbiome feedback limits productivity in aquaponics

This study shows that transferring established microbiomes to aquaponic systems reduces lettuce growth due to pathogen enrichment, highlighting negative feedback mechanisms similar to soil ecology.