SPOP targets the immune transcription factor IRF1 for proteasomal degradation
M. Vunjak, I. Schwartz, A. Cantoran-Garcia, M. Mastrovito, M. Hinterndorfer, M. de Almeida, V. Budroni, J. Wang, K. Froussios, J. Jude, T. Decker, J. Zuber, G. A. Versteeg
This study identifies SPOP as an E3 ligase that targets IRF1 for proteasomal degradation, highlighting its role in regulating IRF1 levels to balance immune response and tumor suppression.
bioRxiv · Oct 10, 2022Cell Biology