Author

I. Schwartz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

G. A. Versteeg· 3 shared V. Budroni· 3 shared J. Zuber· 2 shared K. Froussios· 2 shared K. Hacker· 2 shared S. Scinicariello· 2 shared T. Clausen· 2 shared A. Bestehorn· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCell Biology

G. A. Versteeg

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.

I. Schwartz, V. Budroni, M. Meyenberg, H. Hornegger, K. Hacker, S. Schwartz, Z. Hodakova, D. B. Grabarczyk, J. Ehrmann, S. Scinicariello, D. Haselbach, J. Menche, T. Clausen, E. Karagoez, G. A. Versteeg

The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.

bioRxiv · Apr 23, 2024Cell Biology

Whole genome sequencing of Borrelia burgdorferi isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence.

J. E. Lemieux, W. Huang, N. Hill, T. Cerar, L. Freimark, S. Hernandez, M. Luban, V. Maraspin, P. Bogovic, K. Ogrinc, P. Lapierre, E. Lasek-Nesselquist, N. Singh, R. Iyer, D. Liveris, , K. Strle

This study uses whole genome sequencing of Borrelia burgdorferi isolates to identify plasmid-borne accessory genome elements linked to virulence and dissemination of Lyme disease.

bioRxiv · Feb 26, 2023 · PreprintMicrobiology

SPOP targets the immune transcription factor IRF1 for proteasomal degradation

M. Vunjak, I. Schwartz, A. Cantoran-Garcia, M. Mastrovito, M. Hinterndorfer, M. de Almeida, V. Budroni, J. Wang, K. Froussios, J. Jude, T. Decker, J. Zuber, G. A. Versteeg

This study identifies SPOP as an E3 ligase that targets IRF1 for proteasomal degradation, highlighting its role in regulating IRF1 levels to balance immune response and tumor suppression.

bioRxiv · Oct 10, 2022Cell Biology

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

S. Scinicariello, A. Soederholm, M. Schaefer, A. Shulkina, I. Schwartz, K. Hacker, R. Gogova, R. Kalis, K. Froussios, V. Budroni, A. Bestehorn, T. Clausen, P. Kovarik, J. Zuber, G. A. Versteeg

This study identifies HUWE1 as a regulator of TTP proteasomal degradation by controlling its phosphorylation, distinct from MAPK-mediated phosphorylation.

bioRxiv · Aug 29, 2022Cell Biology