Cell BiologybioRxiv
SPOP targets the immune transcription factor IRF1 for proteasomal degradation
M. Vunjak, I. Schwartz, A. Cantoran-Garcia…·G. A. Versteeg
This study identifies SPOP as an E3 ligase that targets IRF1 for proteasomal degradation, highlighting its role in regulating IRF1 levels to balance immune response and tumor suppression.
DOI 10.7554/elife.89951