Author

M. Hinterndorfer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Cantoran-Garcia· 1 shared A. Ciulli· 1 shared A. Correa-Saez· 1 shared A. D. Cowan· 1 shared A. Rukavina· 1 shared A. Testa· 1 shared C. Craigon· 1 shared C. Maniaci· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCell Biology

A. Cantoran-Garcia

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2 papers

Recent·Most cited

Targeted protein degradation via intramolecular bivalent glues

O. Hsia, M. Hinterndorfer, A. D. Cowan, K. Iso, T. Ishida, R. Sundaramoorthy, M. A. Nakasone, H. Imrichova, C. Schatz, A. Rukavina, K. Husnjak, M. Wegner, A. Correa-Saez, C. Craigon, R. Casement, , A. Ciulli

This paper introduces intramolecular bivalent glues (IBGs) as a new method for targeted protein degradation, showing they enhance ubiquitination by bridging protein domains and improving degradation efficiency.

bioRxiv · Feb 14, 2023Biochemistry

SPOP targets the immune transcription factor IRF1 for proteasomal degradation

M. Vunjak, I. Schwartz, A. Cantoran-Garcia, M. Mastrovito, M. Hinterndorfer, M. de Almeida, V. Budroni, J. Wang, K. Froussios, J. Jude, T. Decker, J. Zuber, G. A. Versteeg

This study identifies SPOP as an E3 ligase that targets IRF1 for proteasomal degradation, highlighting its role in regulating IRF1 levels to balance immune response and tumor suppression.

bioRxiv · Oct 10, 2022Cell Biology