P. Bastin

The ANKS3/BICC1 protein complex is a master post-transcriptional regulator of NPHP1 ciliopathy gene transcripts

The paper identifies ANKS3/BICC1 as a post-transcriptional regulator of NPHP1 transcripts, linking it to ciliopathy phenotypes through transcript decay and ciliary dysfunction.

Novel roles for the LRRC56 protein, an IFT cargo protein, in docking of dynein arms in Trypanosoma brucei

This study identifies LRRC56 as a transient IFT cargo required for docking complex protein attachment in Trypanosoma brucei, revealing its role in ODA docking and flagellar maturation.

Spatial confinement of Trypanosoma brucei in microfluidic traps provides a new tool to study free swimming parasites

This paper develops a microfluidic device to confine Trypanosoma brucei for high-resolution imaging of its motility and behavior.

Separate to operate: the centriole-free inner core of the centrosome regulates the assembly of the intranuclear spindle in Toxoplasma gondii

This study identifies TgCEP250L1 as essential for the inner core of the Toxoplasma gondii centrosome, which regulates mitotic spindle formation and nuclear segregation during cell division.

Concentration of intraflagellar transport proteins at the ciliary base is required for proper train injection

The paper shows that concentrating IFT proteins at the flagellum base is necessary for proper IFT train injection in Trypanosoma brucei.

Redistribution of FLAgellar Member 8 during the trypanosome life cycle: consequences for cell fate prediction.

This study shows FLAM8 distribution changes during the trypanosome life cycle, indicating its role as a marker for flagellum maturation and cell fate prediction.

Intraflagellar transport during the assembly of flagella of different length in Trypanosoma brucei isolated from tsetse flies

This study examines how Trypanosoma brucei modulates flagellum length during development in tsetse flies, finding a correlation between intraflagellar transport protein levels and flagellum length.

Dynamic High-Content Imaging Reveals Surface Exposure Of Virulent Leishmania Amastigotes In Infected Macrophages Undergoing Pyroptosis

This study shows that Leishmania-infected macrophages undergo pyroptosis, exposing amastigotes to the extracellular environment, which may aid parasite spread.

A key regulatory protein for flagellum length control in stable flagella

This paper identifies Cep164C as a key protein involved in maintaining stable flagellum length in Trypanosoma brucei by acting as a molecular lock at the flagellum base.

Timing and original features of flagellum assembly in trypanosomes during development in the tsetse fly

This paper investigates flagellum assembly in Trypanosoma brucei during differentiation in tsetse flies, revealing unique structural and temporal features distinct from procyclic cells.

IFT25 is required for the construction of the trypanosome flagellum

This study shows that IFT25 is essential for flagellum construction in Trypanosoma brucei, forming a specific module with IFT27 that is not required for other cilia types.

A grow-and-lock model for the control of flagellum length in trypanosomes

This paper investigates flagellum length control in Trypanosoma brucei, proposing a 'grow-and-lock' model where flagella elongate until a locking event fixes their length.

Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum

This study identifies two distinct IFT tracks in trypanosome flagella using microscopy, showing bidirectional transport on parallel lines and dynamic conversion of anterograde to retrograde trains.