N. M. B. Brancucci

This study investigates how antimalarial drugs affect gametocyte formation in Plasmodium falciparum, finding that drug-induced effects on sexual commitment are only observed at concentrations that inhibit parasite survival.

This study identifies PfPDK1 as an essential upstream activator of PfPKAc in malaria parasites, crucial for parasite survival and a potential drug target.

This study investigates PfHP1 domains in Plasmodium falciparum using CRISPR/Cas9 and DiCre/LoxP, showing their roles in nuclear targeting, heterochromatin formation, and parasite proliferation.

This paper develops CRISPR/Cas9-engineered inducible gametocyte producer lines for mass production of P. falciparum gametocytes, achieving 75% sexual commitment and enabling genetic studies of transmission stages.

This study uses 3D imaging techniques to visualize Plasmodium parasites in whole, optically cleared Anopheles stephensi mosquitoes without dissection.