M. E. Fernandez-Zapico

The paper identifies a paracrine signaling cascade involving SHH, WNT, and VEGF that suppresses angiogenesis in pancreatic cancer using tumor explant models.

This study identifies PIM inhibitors as synergistic with BET inhibitors in myeloid leukemia, showing miR-33a downregulation drives PIM1 upregulation and GM-CSF hypersensitivity as a biomarker for combination therapy.

This paper investigates the role of SOS1 in colorectal cancer using patient-derived organoids and identifies SOS1 protein expression as a predictive marker for response to SOS1 inhibitors.

The paper shows p97/VCP interacts with RUVBL2 and mSin3A-HDAC1/2 to regulate GLI1, which activates XBP1 under ER stress, independent of Hh ligands.

This study identifies RAS mutations as drivers of proliferative CMML through a novel KMT2A-PLK1 axis, showing PLK1 inhibition can improve disease outcomes in patient-derived xenografts.