p97/VCP induces GLI1 to control XBP1-dependent endoplasmic reticulum stress transcriptional response
K. Barroso, L. L. Almada, R. Olson, H. Auner, R. Pedeux, J. L. IOVANNA, E. Chevet, M. E. Fernandez-Zapico
The paper shows p97/VCP interacts with RUVBL2 and mSin3A-HDAC1/2 to regulate GLI1, which activates XBP1 under ER stress, independent of Hh ligands.
bioRxiv · Feb 24, 2021 · PreprintCancer Biology