Author

G. A. Caldwell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Organism:C. elegans· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

K. A. Caldwell· 2 shared A. Fasano· 1 shared A. M. Lozano· 1 shared A. Tariq· 1 shared C. Burns· 1 shared C. S. Asensio· 1 shared C. Sepulveda· 1 shared C. ten Brink· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

K. A. Caldwell

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Author profile →

2 papers

Recent·Most cited

Tuning Hsp104 specificity to selectively detoxify alpha-synuclein

K. L. Mack, H. Kim, M. E. Jackrel, J. Lin, J. E. DeNizio, X. Yan, E. Chuang, A. Tariq, R. R. Cupo, L. M. Castellano, K. A. Caldwell, G. A. Caldwell, J. Shorter

The paper engineers Hsp104 variants with substrate specificity to selectively reduce alpha-synuclein toxicity in a Parkinson's disease model.

bioRxiv · Apr 15, 2020Bioengineering

VPS41 recessive mutation causes ataxia and dystonia with retinal dystrophy and mental retardation by inhibiting HOPS function and mTORC1 signaling

R. E. N. van der Welle, R. Jobling, C. Burns, P. Sanza, C. ten Brink, A. Fasano, L. Chen, F. J. Zwartkruis, S. Zwakenberg, E. F. Griffin, J. van der Beek, T. Veenendaal, N. Liv, S. Blaser, C. Sepulveda, , J. Klumperman

This paper identifies VPS41 mutations causing neurodegenerative disease by disrupting HOPS function and mTORC1 signaling, leading to lysosomal dysfunction and impaired autophagy.

bioRxiv · Dec 18, 2019 · PreprintCell Biology