RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription
Nitish Jangde, M J Lee, Luz Clarita Ruiz, Isabelle Egan, Anna M. Jermakowicz, Rishika Chowdary, Jonathan Chu, Daniel T. Wynn, Erik T. Goka, M. E. Lippman, David J. Robbins, Nagi G. Ayad
This study identifies RAC1 as a druggable target in Shh-dependent medulloblastoma by showing its role in regulating GLI1 and GLI2 transcription and demonstrating the efficacy of the inhibitor GYS32661 in reducing tumor growth.
Neuro-Oncology · Mar 19, 2026Peer-reviewedPharmacology & Toxicology