Author

W. A. Ricke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:behavioral assay· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. M. Vezina· 4 shared P. Popovics· 3 shared A. Jain· 2 shared E. Schroeder· 2 shared H. M. Ruetten· 2 shared K. O. Skalitzky· 2 shared K. S. Uchtmann· 2 shared A. Bleicher· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersPathology

C. M. Vezina

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Author profile →

5 papers

Recent·Most cited

Steroid hormone imbalance drives macrophage infiltration and Spp1/osteopontin+ foam cell differentiation in the prostate

P. Popovics, K. O. Skalitzky, E. Schroeder, A. Jain, S. V. Silver, F. Van Fritz, K. S. Uchtmann, C. M. Vezina, W. A. Ricke

This study shows that steroid hormone imbalance in mice increases macrophage infiltration and Spp1/osteopontin+ foam cell differentiation in the prostate, with OPN knockout reducing these effects.

bioRxiv · Dec 13, 2022Pathology

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

C. L. Green, M. E. Trautman, R. Babygirija, R. Jain, K. Chaiyakul, H. H. Pak, A. Bleicher, G. Novak, M. M. Sonsalla, C.-Y. Yeh, M. F. Calubag, T. T. Liu, V. Flores, S. Newman, W. A. Ricke, , D. Lamming

This study shows that reducing dietary isoleucine improves metabolic health, reduces frailty, and extends lifespan in genetically diverse mice.

bioRxiv · Oct 6, 2022Physiology

OSTEOPONTIN DEFICIENCY LEADS TO THE RESOLUTION OF PROSTATIC FIBROSIS AND INFLAMMATION

P. Popovics, A. Jain, K. O. Skalitzky, E. Schroeder, H. M. Ruetten, M. Cadena, K. S. Uchtmann, C. M. Vezina, W. A. Ricke

This study shows that OPN deficiency reduces inflammation and fibrosis in the prostate after E. coli infection in mice.

bioRxiv · Jul 19, 2021 · PreprintPathology

Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia

P. Popovics, W. N. Awadallah, S. Kohrt, T. C. Case, N. L. Miller, E. Ricke, W. Huang, M. Ramirez-Solano, Q. Liu, C. M. Vezina, R. J. Matusik, W. A. Ricke, M. M. Grabowska

This study shows that osteopontin (OPN) is more abundant in symptomatic benign prostatic hyperplasia (S-BPH) compared to incidental BPH, and OPN secretion is stimulated by pro-inflammatory cytokines, driving pro-inflammatory gene expression in stromal cells.

bioRxiv · Dec 23, 2019Pathology

Factors Driving Unique Urination Phenotypes of Male and Female 9-week-old C57BL/6J Mice

H. M. RUETTEN, K. A. Wegner, H. L. Zhang, P. Wang, J. K. Sandhu, S. K. Sandhu, B. R. Mueller, Z. Wang, J. Macoska, R. E. Peterson, D. E. Bjorling, W. A. Ricke, P. C. Marker, C. M. Vezina

This study evaluates how prostate mass and testosterone affect voiding function in male and female mice, finding that testosterone, not prostate size, primarily drives sex differences in urinary function.

bioRxiv · May 27, 2019Physiology