M. F. Garcia-Parajo

Differential spatial regulation and activation of integrin nanoclusters inside focal adhesions

The paper uses super-resolution microscopy to show that integrin nanoclusters are spatially segregated within focal adhesions, suggesting coordinated activation through adaptor nanoclusters.

Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells

This study shows that actin-regulated Siglec-1 nanoclustering in activated dendritic cells enhances HIV-1 capture and trafficking into a single viral-containing compartment.

Sorting of secretory proteins at the trans-Golgi network by human TGN46

This study identifies TGN46 as a receptor for sorting secretory cargo protein PAUF into TGN-to-plasma membrane carriers, showing its lumenal domain is essential for cargo sorting.

Phase separation of tunable biomolecular condensates predicted by an interacting particle model

The paper develops a theoretical model of phase separation using interaction probabilities and validates it with single-molecule experiments on transcription factor condensates.

Shear flow-driven actin re-organization induces ICAM-1 nanoclustering on endothelial cells that impact T-cell migration

This study shows that shear forces induce ICAM-1 nanoclustering on endothelial cells through actin re-organization, enhancing T-cell migration by strengthening adhesion and reducing actin retrograde flow.

A physical mechanism of TANGO1-mediated bulky cargo export

This paper presents a physical model explaining how TANGO1 stabilizes ER membrane tension to facilitate procollagen export from the ER.

Membrane receptor MerTK is a newly identified transcriptional regulator that associates to chromatin as nanoclusters during human DC differentiation

This study identifies MerTK as a transcriptional regulator in human dendritic cells, showing its nuclear translocation and clustering during differentiation.

Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane

This study reveals that CD44 forms a meso-scale meshwork at the plasma membrane, regulated by actin dynamics and nano-scale clustering.