S. Mayor

Growth factor-induced desialylation for the fast control of endocytosis

The paper shows that growth factors induce rapid desialylation of cell surface glycoproteins, enabling reversible changes in glycan structure and function through galectin-mediated endocytosis.

Quantitative fluorescence emission anisotropy microscopy for implementing homo-FRET measurements in living cells.

This paper describes methods for quantitative fluorescence emission anisotropy microscopy to measure homo-FRET in living cells and identifies key parameters affecting accuracy.

Active emulsions in living cell membranes driven by contractile stresses and transbilayer coupling

The paper investigates how active contractile stresses and transbilayer coupling drive the formation of mesoscopic domains in cell membranes containing GPI-APs and lipids.

Cellular compartmentalisation and receptor promiscuity as a strategy for accurate and robust inference of position during morphogenesis

The paper shows how cells use compartmentalisation and multiple receptors to accurately infer their position during morphogenesis, using Drosophila wing disc development as a case study.

Inhibition of HIV-1 immune modulation by small molecules targeting viral Nef-host CD80 interface

The paper identifies small molecules that inhibit HIV-1 Nef's down-regulation of CD80/86, restoring T-cell activation by targeting the Nef-CD80 interface.

An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion

The paper explains how E-cadherin-actin interactions mediate mechanical signals from cortical flows to inhibit epithelial cell migration based on contact orientation.

Niclosamide inhibits SARS-CoV2 entry by blocking internalization through pH-dependent CLIC/GEEC endocytic pathway

Cargo-specific recruitment in clathrin and dynamin-independent endocytosis

The paper identifies swiprosin-1 as a cargo-specific adaptor for the CG-pathway, showing its role in integrin internalization and breast cancer progression.

Plk4 triggers autonomous de novo centriole biogenesis and maturation

This study shows Plk4 drives de novo centriole formation, maturation, and duplication independently of cell cycle and existing centrioles.

Visualization of myosin II filament dynamics in remodeling acto-myosin networks with interferometric scattering microscopy

This study uses interferometric scattering microscopy to visualize myosin II filament dynamics in acto-myosin networks, showing how ATP concentration affects dwell times and network remodeling.

The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity

This study shows that the bacterial QS molecule DSF suppresses Arabidopsis innate immunity by altering sterol biosynthesis and disrupting FLS2 receptor dynamics.

DISTINCT ACTIN-DEPENDENT NANOSCALE ASSEMBLIES UNDERLIE THE DYNAMIC AND HIERARCHICAL ORGANIZATION OF E-CADHERIN.

This study investigates the nanoscale organization of E-cadherin at cell-cell junctions and shows that cortical actomyosin dynamically remodels oligomers and stabilizes nanoclusters.

Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane

This study reveals that CD44 forms a meso-scale meshwork at the plasma membrane, regulated by actin dynamics and nano-scale clustering.

Assemblies of F-actin and myosin-II minifilaments: steric hindrance and stratification at the membrane cortex

The paper investigates how steric hindrance and stratification affect actomyosin organization, showing that simulations and microscopy reveal stratified patterns in vitro that differ from in vivo observations.

Phosphorylation of Nephrin induces phase separated domains that move through actomyosin contraction

This study shows phosphorylated Nephrin forms phase-separated domains at the plasma membrane, which move via actomyosin contraction.

A Composition-Dependent Molecular Clutch Between T Cell Signaling Clusters and Actin

The paper investigates how Nck and WASP mediate the movement of LAT condensates across actin networks during T cell activation.

Mechanochemical feedback and control of endocytosis and membrane tension

The paper identifies a negative feedback loop between membrane tension and the CLIC/GEEC pathway mediated by vinculin and GBF1.

Small GTPases and BAR domain proteins regulate branched actin to make clathrin and dynamin independent endocytic vesicles

This study identifies the molecular machinery regulating clathrin and dynamin-independent endocytic vesicles, showing the sequential recruitment of ARF1/GBF1 and CDC42, and the roles of BAR domain proteins and actin polymerization.

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

The paper shows that integrin orientation is dictated by actin flow direction and cytoskeletal forces during leukocyte migration.

A DNA-based T cell receptor reveals a role for receptor clustering in ligand discrimination

This study uses DNA-based T cell receptors to show that receptor clustering enhances ligand discrimination by enabling kinetic proofreading.