Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation
Y. Yang, M. C. Brown, G. Zhang, K. Stevenson, M. Mohme, R. Kornahrens, D. D. Bigner, D. M. Ashley, G. Y. Lopez, M. Gromeier
This study investigates how PVSRIPO virotherapy activates microglia and myeloid cells in gliomas, leading to antitumor inflammation and improved outcomes when combined with PD1/PD-L1 blockade.
bioRxiv · Apr 19, 2022 · PreprintCancer Biology