Author

M. J. Henley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Mapp· 2 shared S. T. Joy· 2 shared A. J. L. Huldin· 1 shared A. K. Mapp· 1 shared B. M. Linhares· 1 shared B. S. Morgan· 1 shared C. A. Fierke· 1 shared I. W. Vock· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

A. Mapp

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Author profile →

3 papers

Recent·Most cited

Inhibition of CREB binding and function with a dual-targeting ligand

Y. Liu, S. T. Joy, M. J. Henley, J. A. Yates, S. D. Merajver, A. K. Mapp

This study develops a dual-targeting ligand, CREBLL-tide, that inhibits the KIX-CREB PPI with high potency and selectivity, showing anti-proliferation activity in breast cancer cells.

bioRxiv · Sep 3, 2023Biochemistry

A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb

S. T. Joy, M. J. Henley, S. N. De Salle, M. J. Beyersdorf, I. W. Vock, A. J. L. Huldin, A. Mapp

This paper develops a dual-site inhibitor, MybLL-tide, that selectively targets the CBP/p300 KIX domain, inhibiting Myb-dependent gene expression in AML cells.

bioRxiv · Apr 28, 2021Biochemistry

Unexpected Specificity within Dynamic Transcriptional Protein-Protein Complexes

M. J. Henley, B. M. Linhares, B. S. Morgan, C. A. Fierke, T. Cierpicki, A. Mapp

The paper investigates the molecular recognition of disordered activators by coactivators, revealing that specific contacts and coactivator plasticity drive specificity despite apparent nonspecific interactions.

bioRxiv · May 29, 2020Biochemistry