Author

M. W. Mather

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:plant (other)· 6 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

A. B. Vaidya· 6 shared J. M. Morrisey· 5 shared H. Ke· 4 shared M. K. Riscoe· 3 shared S. Dass· 3 shared A. Shukla· 2 shared L. Ling· 2 shared M. Llinas· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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6 shared papersMicrobiology

A. B. Vaidya

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mutational Analysis of an Antimalarial Drug Target PfATP4

S. Rachuri, B. Nepal, A. Shukla, A. A. Ramanathan, J. M. Morrisey, T. M. Daly, M. W. Mather, L. W. Bergman, S. Kortagere, A. B. Vaidya

The paper models PfATP4 structure using homology and validates predictions through genetic manipulation, identifying key residues for function and resistance.

bioRxiv · Feb 21, 2024 · PreprintMicrobiology

Genetic disruption of isocitrate dehydrogenase arrests the full development of sexual stage parasites in Plasmodium falciparum

M. Yang, H. Ke, J. M. Morrisey, M. W. Mather, A. B. Vaidya

This study shows that knocking out isocitrate dehydrogenase (IDH) in Plasmodium falciparum parasites arrests gametocyte development, similar to aconitase knockout, and suggests IDH as a potential target for malaria transmission control.

bioRxiv · Aug 5, 2022 · PreprintMicrobiology

Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum

I. M. Lamb, K. T. Rios, A. Shukla, A. I. Ahiya, J. M. Morrisey, J. C. Mell, S. E. Lindner, M. W. Mather, A. B. Vaidya

The paper identifies 122 putative mitochondrial proteins in Plasmodium falciparum using proximity biotinylation and mass spectrometry, with four confirmed mitochondrial proteins of unknown function.

bioRxiv · May 30, 2022 · PreprintMicrobiology

Transcriptional changes in Plasmodium falciparum upon conditional knock down of mitochondrial ribosomal proteins RSM22 and L23

S. Dass, M. W. Mather, L. Ling, A. B. Vaidya, H. Ke

This study investigates the effects of conditional knockdown of mitochondrial ribosomal proteins RSM22 and L23 in Plasmodium falciparum, revealing distinct transcriptional responses and metabolic defects leading to parasite death.

bioRxiv · Feb 9, 2022 · PreprintMicrobiology

Atypical molecular basis for drug resistance to mitochondrial function inhibitors in Plasmodium falciparum

H. J. Painter, J. M. Morrisey, M. W. Mather, L. M. Orchard, C. Luck, M. J. Smilkstein, M. K. Riscoe, A. B. Vaidya, M. Llinas

This study identifies a novel mechanism of drug resistance in Plasmodium falciparum involving copy number variation and a SNP in pfdhodh, leading to pan-resistance to mtETC and DHODH inhibitors.

bioRxiv · Oct 8, 2020Microbiology

Genetic ablation of the mitochondrial ribosome in Plasmodium falciparum sensitizes the human malaria parasite to antimalarial drugs targeting mitochondrial functions

L. Ling, M. Mulaka, J. Munro, S. Dass, M. W. Mather, M. K. Riscoe, M. Llinas, J. Zhou, H. Ke

This study shows that disrupting the mitochondrial ribosome in Plasmodium falciparum makes the parasite more sensitive to drugs targeting mitochondrial functions.

bioRxiv · Jan 14, 2020 · PreprintBiochemistry

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum is dispensable and not the functional target of putative NDH2 quinolone inhibitors

H. Ke, S. M. Ganesan, S. Dass, J. M. Morrisey, S. Pou, A. Nilsen, M. K. Riscoe, M. W. Mather, A. B. Vaidya

This paper shows that PfNDH2 in Plasmodium falciparum is not essential and that purported NDH2 inhibitors actually target the cytochrome bc1 complex.

bioRxiv · Oct 5, 2018Microbiology