Author

L. M. Orchard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:plant (other)· 2 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

H. J. Painter· 2 shared M. Llinas· 2 shared A. B. Vaidya· 1 shared B. F. C. Kafsack· 1 shared C. Luck· 1 shared D. Patel· 1 shared J. M. Morrisey· 1 shared J. M. Santos· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

H. J. Painter

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The PfAP2-G2 transcription factor is a critical regulator of gametocyte maturation

S. Singh, J. M. Santos, L. M. Orchard, N. Yamada, R. van Biljon, H. J. Painter, S. Mahony, M. Llinas

This study identifies PfAP2-G2 as a critical transcription factor for Plasmodium falciparum gametocyte maturation, showing it regulates gene expression and interacts with chromatin remodeling proteins.

bioRxiv · Oct 27, 2020Microbiology

The essential transcriptional regulator HDP1 drives expansion of the inner membrane complex during early sexual differentiation of malaria parasites.

R. Campelo Morillo, X. Tong, W. Xie, S. Abel, L. M. Orchard, W. Daher, D. Patel, W. S. Noble, K. G. Le Roch, B. F. C. Kafsack

This study identifies HDP1 as a transcriptional regulator essential for upregulating inner membrane complex genes during early gametocytogenesis in Plasmodium falciparum.

bioRxiv · Oct 26, 2020 · PreprintMicrobiology

Atypical molecular basis for drug resistance to mitochondrial function inhibitors in Plasmodium falciparum

H. J. Painter, J. M. Morrisey, M. W. Mather, L. M. Orchard, C. Luck, M. J. Smilkstein, M. K. Riscoe, A. B. Vaidya, M. Llinas

This study identifies a novel mechanism of drug resistance in Plasmodium falciparum involving copy number variation and a SNP in pfdhodh, leading to pan-resistance to mtETC and DHODH inhibitors.

bioRxiv · Oct 8, 2020Microbiology