Author

A. B. Vaidya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10

Signature Assays, Organisms & Methods

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Organism:plant (other)· 8 Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Organism:human· 2

Frequent Co-Authors

J. M. Morrisey· 7 shared M. W. Mather· 6 shared H. Ke· 3 shared S. Bhatnagar· 3 shared A. I. Ahiya· 2 shared A. Shukla· 2 shared D. E. Goldberg· 2 shared J. R. Beck· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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7 shared papersMicrobiology

J. M. Morrisey

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10 papers

Recent·Most cited

Mutational Analysis of an Antimalarial Drug Target PfATP4

S. Rachuri, B. Nepal, A. Shukla, A. A. Ramanathan, J. M. Morrisey, T. M. Daly, M. W. Mather, L. W. Bergman, S. Kortagere, A. B. Vaidya

The paper models PfATP4 structure using homology and validates predictions through genetic manipulation, identifying key residues for function and resistance.

bioRxiv · Feb 21, 2024 · PreprintMicrobiology

Detailing organelle division and segregation in Plasmodium falciparum

J. M. J. Verhoef, C. Boshoven, F. Evers, L. J. Akkerman, B. C. A. Gijsbrechts, M. van de Vegte-Bolmer, G.-J. van Gemert, A. B. Vaidya, T. W. A. Kooij

This study details the division and segregation of mitochondria and apicoplasts in Plasmodium falciparum using imaging and microscopy techniques.

bioRxiv · Jan 30, 2024 · PreprintMicrobiology

Genetic disruption of isocitrate dehydrogenase arrests the full development of sexual stage parasites in Plasmodium falciparum

M. Yang, H. Ke, J. M. Morrisey, M. W. Mather, A. B. Vaidya

This study shows that knocking out isocitrate dehydrogenase (IDH) in Plasmodium falciparum parasites arrests gametocyte development, similar to aconitase knockout, and suggests IDH as a potential target for malaria transmission control.

bioRxiv · Aug 5, 2022 · PreprintMicrobiology

Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum

I. M. Lamb, K. T. Rios, A. Shukla, A. I. Ahiya, J. M. Morrisey, J. C. Mell, S. E. Lindner, M. W. Mather, A. B. Vaidya

The paper identifies 122 putative mitochondrial proteins in Plasmodium falciparum using proximity biotinylation and mass spectrometry, with four confirmed mitochondrial proteins of unknown function.

bioRxiv · May 30, 2022 · PreprintMicrobiology

Transcriptional changes in Plasmodium falciparum upon conditional knock down of mitochondrial ribosomal proteins RSM22 and L23

S. Dass, M. W. Mather, L. Ling, A. B. Vaidya, H. Ke

This study investigates the effects of conditional knockdown of mitochondrial ribosomal proteins RSM22 and L23 in Plasmodium falciparum, revealing distinct transcriptional responses and metabolic defects leading to parasite death.

bioRxiv · Feb 9, 2022 · PreprintMicrobiology

Dramatic consequences of reducing erythrocyte membrane cholesterol on Plasmodium falciparum

A. I. Ahiya, S. Bhatnagar, J. M. Morrisey, J. R. Beck, A. B. Vaidya

This paper shows that reducing erythrocyte membrane cholesterol with MβCD causes rapid expulsion of Plasmodium falciparum trophozoites, and antimalarials targeting PfATP4 or PfNCR1 inhibit this process.

bioRxiv · Oct 6, 2021Microbiology

Atypical molecular basis for drug resistance to mitochondrial function inhibitors in Plasmodium falciparum

H. J. Painter, J. M. Morrisey, M. W. Mather, L. M. Orchard, C. Luck, M. J. Smilkstein, M. K. Riscoe, A. B. Vaidya, M. Llinas

This study identifies a novel mechanism of drug resistance in Plasmodium falciparum involving copy number variation and a SNP in pfdhodh, leading to pan-resistance to mtETC and DHODH inhibitors.

bioRxiv · Oct 8, 2020Microbiology

Diverse chemical compounds target Plasmodium falciparum plasma membrane lipid homeostasis

S. Bhatnagar, S. Nicklas, J. M. Morrisey, D. E. Goldberg, A. B. Vaidya

The paper screens compounds to identify those disrupting Plasmodium falciparum plasma membrane lipid homeostasis, finding some act independently of Na+ homeostasis and target PfNCR1.

bioRxiv · Oct 16, 2018Microbiology

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum is dispensable and not the functional target of putative NDH2 quinolone inhibitors

H. Ke, S. M. Ganesan, S. Dass, J. M. Morrisey, S. Pou, A. Nilsen, M. K. Riscoe, M. W. Mather, A. B. Vaidya

This paper shows that PfNDH2 in Plasmodium falciparum is not essential and that purported NDH2 inhibitors actually target the cytochrome bc1 complex.

bioRxiv · Oct 5, 2018Microbiology

Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis

E. S. Istvan, S. Das, S. Bhatnagar, J. R. Beck, E. Owen, M. LLinas, S. M. Ganesan, J. C. Niles, E. A. Winzeler, A. B. Vaidya, D. E. Goldberg

This study identifies PfNCR1 as a critical protein for Plasmodium falciparum membrane homeostasis and shows it is a potential druggable target for antimalarial drugs.

bioRxiv · Jul 26, 2018Microbiology