Author

J. M. Morrisey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:plant (other)· 5 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

A. B. Vaidya· 7 shared M. W. Mather· 5 shared A. I. Ahiya· 2 shared A. Shukla· 2 shared H. Ke· 2 shared M. K. Riscoe· 2 shared S. Bhatnagar· 2 shared A. A. Ramanathan· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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7 shared papersMicrobiology

A. B. Vaidya

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7 papers

Recent·Most cited

Mutational Analysis of an Antimalarial Drug Target PfATP4

S. Rachuri, B. Nepal, A. Shukla, A. A. Ramanathan, J. M. Morrisey, T. M. Daly, M. W. Mather, L. W. Bergman, S. Kortagere, A. B. Vaidya

The paper models PfATP4 structure using homology and validates predictions through genetic manipulation, identifying key residues for function and resistance.

bioRxiv · Feb 21, 2024 · PreprintMicrobiology

Genetic disruption of isocitrate dehydrogenase arrests the full development of sexual stage parasites in Plasmodium falciparum

M. Yang, H. Ke, J. M. Morrisey, M. W. Mather, A. B. Vaidya

This study shows that knocking out isocitrate dehydrogenase (IDH) in Plasmodium falciparum parasites arrests gametocyte development, similar to aconitase knockout, and suggests IDH as a potential target for malaria transmission control.

bioRxiv · Aug 5, 2022 · PreprintMicrobiology

Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum

I. M. Lamb, K. T. Rios, A. Shukla, A. I. Ahiya, J. M. Morrisey, J. C. Mell, S. E. Lindner, M. W. Mather, A. B. Vaidya

The paper identifies 122 putative mitochondrial proteins in Plasmodium falciparum using proximity biotinylation and mass spectrometry, with four confirmed mitochondrial proteins of unknown function.

bioRxiv · May 30, 2022 · PreprintMicrobiology

Dramatic consequences of reducing erythrocyte membrane cholesterol on Plasmodium falciparum

A. I. Ahiya, S. Bhatnagar, J. M. Morrisey, J. R. Beck, A. B. Vaidya

This paper shows that reducing erythrocyte membrane cholesterol with MβCD causes rapid expulsion of Plasmodium falciparum trophozoites, and antimalarials targeting PfATP4 or PfNCR1 inhibit this process.

bioRxiv · Oct 6, 2021Microbiology

Atypical molecular basis for drug resistance to mitochondrial function inhibitors in Plasmodium falciparum

H. J. Painter, J. M. Morrisey, M. W. Mather, L. M. Orchard, C. Luck, M. J. Smilkstein, M. K. Riscoe, A. B. Vaidya, M. Llinas

This study identifies a novel mechanism of drug resistance in Plasmodium falciparum involving copy number variation and a SNP in pfdhodh, leading to pan-resistance to mtETC and DHODH inhibitors.

bioRxiv · Oct 8, 2020Microbiology

Diverse chemical compounds target Plasmodium falciparum plasma membrane lipid homeostasis

S. Bhatnagar, S. Nicklas, J. M. Morrisey, D. E. Goldberg, A. B. Vaidya

The paper screens compounds to identify those disrupting Plasmodium falciparum plasma membrane lipid homeostasis, finding some act independently of Na+ homeostasis and target PfNCR1.

bioRxiv · Oct 16, 2018Microbiology

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum is dispensable and not the functional target of putative NDH2 quinolone inhibitors

H. Ke, S. M. Ganesan, S. Dass, J. M. Morrisey, S. Pou, A. Nilsen, M. K. Riscoe, M. W. Mather, A. B. Vaidya

This paper shows that PfNDH2 in Plasmodium falciparum is not essential and that purported NDH2 inhibitors actually target the cytochrome bc1 complex.

bioRxiv · Oct 5, 2018Microbiology