Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer
M. Pariollaud, L. H. Ibrahim, E. Irizarry, R. M. Mello, A. B. Chan, B. J. Altman, R. J. Shaw, M. J. Bollong, L. Wiseman, K. A. Lamia
This study shows that chronic circadian disruption increases tumor burden in KRAS-driven lung cancer by enhancing HSF1 signaling and tumorigenesis.
bioRxiv · Jan 31, 2022Cell Biology