R. Stephens

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication

This study identifies TRIM7 as an E3-ubiquitin ligase that ubiquitinates SARS-CoV-2 M protein to inhibit apoptosis and viral replication.

Boosting Live Malaria Vaccine with Cytomegalovirus Vector Can Prolong Immunity through Innate and Adaptive Mechanisms

This paper shows that boosting a malaria vaccine with a cytomegalovirus vector prolongs immunity by enhancing T cell responses and innate immune mechanisms involving IFN-γ.

Effects of Low-level Persistent Infection on maintenance of immunity by CD4 T cell subsets and Th1 cytokines

This study investigates how low-level persistent Plasmodium infection affects CD4 T cell subsets and Th1 cytokines, showing that it reduces Tmem survival and promotes specific effector memory cells that prolong immunity.

Structural basis of the human Scribble-Vangl2 association in health and disease

This study determines the crystal structures of Scribble PDZ domains bound to Vangl2 and shows how mutations disrupt interactions with multiple signaling regulators.

Increased Th1 bias in memory T cells corresponds with protection from reinfection in Plasmodium infection, and is regulated by T cell-intrinsic STAT3

The paper shows that STAT3 regulates Th1 bias in memory T cells during Plasmodium infection, enhancing protection from reinfection.

Harnessing patient-specific response dynamics to optimize evolutionary therapies for metastatic clear cell renal cell carcinoma - Learning to adapt

This paper develops a dynamic tumor-immune model to predict patient response to treatment using NLR as a biomarker and simulates optimal therapies for virtual RCC patients.