Author

M. L. Arral

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

K. A. Whitehead· 2 shared A. Majumder· 1 shared A. Malaney· 1 shared A. N. Newby· 1 shared A. Tsourkas· 1 shared B. Channer· 1 shared B. Fox· 1 shared C. A. Hunter· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

K. A. Whitehead

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Author profile →

2 papers

Recent·Most cited

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects

S. Omo-Lamai, Y. Wang, M. N. Patel, E.-o. Essien, M. Shen, A. Majumder, C. Espy, J. Wu, B. Channer, M. P. Tobin, S. Murali, T. E. Papp, R. Maheshwari, L. Wang, L. S. Chase, , J. S. Brenner

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

bioRxiv · Apr 16, 2024 · PreprintBioengineering

Lipid nanoparticle structure and delivery route during pregnancy dictates mRNA potency, immunogenicity, and health in the mother and offspring

N. Chaudhary, A. N. Newby, M. L. Arral, S. S. Yerneni, S. T. LoPresti, R. Doerfler, D. M. S. Petersen, B. Fox, T. Coon, A. Malaney, Y. Sadovsky, K. A. Whitehead

This study identifies LNP structures that deliver mRNA effectively and safely during pregnancy, showing how their composition affects immunogenicity, maternal organ expression, and offspring health.

bioRxiv · Feb 15, 2023 · PreprintBioengineering