M. M. Barr

Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes

The paper identifies cargo proteins associated with polycystin EVs in C. elegans using a modular proximity labeling approach, revealing their role in EV subtype specificity.

NEKL-4 regulates microtubule stability and mitochondrial health in C. elegans ciliated neurons

This study shows NEKL-4 regulates ciliary stability and mitochondrial health in C. elegans ciliated neurons through kinesin activation and mitochondrial homeostasis.

Cell-specific alpha-tubulin TBA-6 and pan-ciliary IFT cargo RAB-28 generate a non-canonical transition zone

The paper identifies cell-specific tubulin and IFT cargo proteins that generate a non-canonical transition zone in cilia through microtubule loss and reorganization.

Ciliary intrinsic mechanisms regulate dynamic ciliary extracellular vesicle release from sensory neurons

This study identifies ciliary intrinsic mechanisms that regulate dynamic extracellular vesicle release from sensory neurons in C. elegans, showing that KLP-6 and TTM-5 are required for sustained release.

Tracking N-and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles

Tracking extracellular vesicle (EV) cargo as a platform for studying EVomics, signaling, and targeting in vivo

The paper presents a platform using C. elegans to track extracellular vesicles and identify their cargo, demonstrating animal-to-animal EV targeting during mating.

Sensory cilia act as a specialized venue for regulated EV biogenesis and signaling

This study identifies ciliary tip and base as distinct sites for EV shedding in C. elegans and shows ciliary trafficking machinery regulates EV biogenesis and signaling.

CCP1, a tubulin deglutamylase, increases survival of rodent spinal cord neurons following glutamate-induced excitotoxicity

This study shows CCP1 protects spinal cord neurons from excitotoxic death by regulating axonal and dendritic MTs, and its expression is reduced after injury.

Polycystin-2 ciliary extracellular vesicle release and targeting

This study identifies PKD-2-carrying ciliary EVs as mechanoresponsive and directionally transferred in C. elegans, suggesting conserved mechanisms across species.

A ciliary BBSome-ARL-6-PDE6D pathway trafficks RAB-28, a negative regulator of extracellular vesicle biogenesis

This study identifies a ciliary pathway involving RAB28, BBSome, and PDE6D that regulates extracellular vesicle biogenesis and homeostasis in C. elegans sensory organs.

Cell type-specific structural plasticity of the ciliary transition zone in C. elegans

The paper shows that ciliary transition zones in C. elegans sensory neurons are structurally plastic, changing during development in a cell type-specific manner.